The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones

Background: Inhalation of lead oxide fumes may cause lead poisoning. Lead has been proven to have harmful effects on different organs. This study aimed to investigate the relationship between the concentration of lead fumes and the levels of reproductive hormones among exposed welders. Methods: A to...

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Autores principales:	Somayeh Farhang Dehghan, Younes Mehrifar, Arash Ardalan
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3c38b05854f54d06a2a48befdbd6aba1
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spelling	oai:doaj.org-article:3c38b05854f54d06a2a48befdbd6aba12021-12-02T05:38:41ZThe Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones2214-999610.5334/aogh.2617https://doaj.org/article/3c38b05854f54d06a2a48befdbd6aba12019-10-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2617https://doaj.org/toc/2214-9996Background: Inhalation of lead oxide fumes may cause lead poisoning. Lead has been proven to have harmful effects on different organs. This study aimed to investigate the relationship between the concentration of lead fumes and the levels of reproductive hormones among exposed welders. Methods: A total number of 165 individuals of a construction industry of water pipelines, including 85 welders as the exposure group and 80 administrative staff as the non-exposure group were selected for study. The National Institute for Occupational Safety and Health (NIOSH) 7300 method was used for the purpose of sampling and analysis of lead fumes. Likewise, the NIOSH 8003 method was employed to determine the blood lead level. The level of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured by Chemiluminescence immunoassay(CLIA) test. Data analyses were done by SPSS ver.21 using descriptive statistics, Student›s t-test and Spearman›s correlation test. Results: The average concentration of lead fumes in the breathing zone and blood were 0.57 ± 0.12 mg/m3 and 460.28 ± 93.65 μg/L, correspondingly, which both were significantly higher than threshold limit values (TLV) and biological exposure index (BEI) recommended by American Conference of Governmental Industrial Hygienists (ACGIH)(P < 0.05). The mean levels of LH and FSH were higher in the exposed group than those in the control group (P < 0.05), however, the mean levels of testosterone were lower in the exposed group compared to non-exposed ones (P < 0.05). A strong correlation was found between the concentration of lead fumes and the blood lead levels (r = 0.82; P = 0.003). Blood lead levels were inversely related to the testosterone levels and directly related to LH (r = 0.72; P = 0.004) and FSH (r = 0.78; P = 0.001) levels. Conclusions: Occupational exposure to metal fumes containing lead among welders may alter the level of sexual hormones and potentially harm the reproductive system.Somayeh Farhang DehghanYounes MehrifarArash ArdalanUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Somayeh Farhang Dehghan Younes Mehrifar Arash Ardalan The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
description	Background: Inhalation of lead oxide fumes may cause lead poisoning. Lead has been proven to have harmful effects on different organs. This study aimed to investigate the relationship between the concentration of lead fumes and the levels of reproductive hormones among exposed welders. Methods: A total number of 165 individuals of a construction industry of water pipelines, including 85 welders as the exposure group and 80 administrative staff as the non-exposure group were selected for study. The National Institute for Occupational Safety and Health (NIOSH) 7300 method was used for the purpose of sampling and analysis of lead fumes. Likewise, the NIOSH 8003 method was employed to determine the blood lead level. The level of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured by Chemiluminescence immunoassay(CLIA) test. Data analyses were done by SPSS ver.21 using descriptive statistics, Student›s t-test and Spearman›s correlation test. Results: The average concentration of lead fumes in the breathing zone and blood were 0.57 ± 0.12 mg/m3 and 460.28 ± 93.65 μg/L, correspondingly, which both were significantly higher than threshold limit values (TLV) and biological exposure index (BEI) recommended by American Conference of Governmental Industrial Hygienists (ACGIH)(P < 0.05). The mean levels of LH and FSH were higher in the exposed group than those in the control group (P < 0.05), however, the mean levels of testosterone were lower in the exposed group compared to non-exposed ones (P < 0.05). A strong correlation was found between the concentration of lead fumes and the blood lead levels (r = 0.82; P = 0.003). Blood lead levels were inversely related to the testosterone levels and directly related to LH (r = 0.72; P = 0.004) and FSH (r = 0.78; P = 0.001) levels. Conclusions: Occupational exposure to metal fumes containing lead among welders may alter the level of sexual hormones and potentially harm the reproductive system.
format	article
author	Somayeh Farhang Dehghan Younes Mehrifar Arash Ardalan
author_facet	Somayeh Farhang Dehghan Younes Mehrifar Arash Ardalan
author_sort	Somayeh Farhang Dehghan
title	The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
title_short	The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
title_full	The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
title_fullStr	The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
title_full_unstemmed	The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones
title_sort	relationship between exposure to lead-containing welding fumes and the levels of reproductive hormones
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/3c38b05854f54d06a2a48befdbd6aba1
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The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones

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