Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure

Abstract Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB fu...

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Autores principales:	Rodrigo Del Rio, David C. Andrade, Camilo Toledo, Hugo S. Diaz, Claudia Lucero, Alexis Arce-Alvarez, Noah J. Marcus, Harold D. Schultz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c398af493fa40f996a13cc1cfaeb087
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spelling	oai:doaj.org-article:3c398af493fa40f996a13cc1cfaeb0872021-12-02T12:32:19ZCarotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure10.1038/s41598-017-08142-32045-2322https://doaj.org/article/3c398af493fa40f996a13cc1cfaeb0872017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08142-3https://doaj.org/toc/2045-2322Abstract Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB function. Then, we hypothesized that the CB-mediated chemoreflex drive will be enhanced only in low output HF but not in high output HF. Myocardial infarcted rats and aorto-caval fistulated rats were used as a low output HF model (MI-CHF) and as a high output HF model (AV-CHF), respectively. Blood flow supply to the CB region was decreased only in MI-CHF rats compared to Sham and AV-CHF rats. MI-CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats. However, apnea/hypopnea incidence was similarly increased in both MI-CHF and AV-CHF rats compared to control. Kruppel-like factor 2 expression, a flow sensitive transcription factor, was reduced in the CBs of MI-CHF rats but not in AV-CHF rats. Our results indicate that in the setting of HF, potentiation of the CB chemoreflex is strongly associated with a reduction in cardiac output and may not be related to other pathophysiological consequences of HF.Rodrigo Del RioDavid C. AndradeCamilo ToledoHugo S. DiazClaudia LuceroAlexis Arce-AlvarezNoah J. MarcusHarold D. SchultzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rodrigo Del Rio David C. Andrade Camilo Toledo Hugo S. Diaz Claudia Lucero Alexis Arce-Alvarez Noah J. Marcus Harold D. Schultz Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
description	Abstract Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB function. Then, we hypothesized that the CB-mediated chemoreflex drive will be enhanced only in low output HF but not in high output HF. Myocardial infarcted rats and aorto-caval fistulated rats were used as a low output HF model (MI-CHF) and as a high output HF model (AV-CHF), respectively. Blood flow supply to the CB region was decreased only in MI-CHF rats compared to Sham and AV-CHF rats. MI-CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats. However, apnea/hypopnea incidence was similarly increased in both MI-CHF and AV-CHF rats compared to control. Kruppel-like factor 2 expression, a flow sensitive transcription factor, was reduced in the CBs of MI-CHF rats but not in AV-CHF rats. Our results indicate that in the setting of HF, potentiation of the CB chemoreflex is strongly associated with a reduction in cardiac output and may not be related to other pathophysiological consequences of HF.
format	article
author	Rodrigo Del Rio David C. Andrade Camilo Toledo Hugo S. Diaz Claudia Lucero Alexis Arce-Alvarez Noah J. Marcus Harold D. Schultz
author_facet	Rodrigo Del Rio David C. Andrade Camilo Toledo Hugo S. Diaz Claudia Lucero Alexis Arce-Alvarez Noah J. Marcus Harold D. Schultz
author_sort	Rodrigo Del Rio
title	Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
title_short	Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
title_full	Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
title_fullStr	Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
title_full_unstemmed	Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
title_sort	carotid body-mediated chemoreflex drive in the setting of low and high output heart failure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3c398af493fa40f996a13cc1cfaeb087
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Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure

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