Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

The thymus supports T cell immunity by providing the environment for thymocyte differentiation. Here the authors profile human thymic stroma at the single cell level, identifying ionocytes as a new medullary population and defining tissue specific antigen expression in multiple stromal cell types.

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Autores principales:	Jhoanne L. Bautista, Nathan T. Cramer, Corey N. Miller, Jessica Chavez, David I. Berrios, Lauren E. Byrnes, Joe Germino, Vasilis Ntranos, Julie B. Sneddon, Trevor D. Burt, James M. Gardner, Chun J. Ye, Mark S. Anderson, Audrey V. Parent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c3cfdba2df144faad4bed7327a4f1bd
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spelling	oai:doaj.org-article:3c3cfdba2df144faad4bed7327a4f1bd2021-12-02T14:21:27ZSingle-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla10.1038/s41467-021-21346-62041-1723https://doaj.org/article/3c3cfdba2df144faad4bed7327a4f1bd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21346-6https://doaj.org/toc/2041-1723The thymus supports T cell immunity by providing the environment for thymocyte differentiation. Here the authors profile human thymic stroma at the single cell level, identifying ionocytes as a new medullary population and defining tissue specific antigen expression in multiple stromal cell types.Jhoanne L. BautistaNathan T. CramerCorey N. MillerJessica ChavezDavid I. BerriosLauren E. ByrnesJoe GerminoVasilis NtranosJulie B. SneddonTrevor D. BurtJames M. GardnerChun J. YeMark S. AndersonAudrey V. ParentNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jhoanne L. Bautista Nathan T. Cramer Corey N. Miller Jessica Chavez David I. Berrios Lauren E. Byrnes Joe Germino Vasilis Ntranos Julie B. Sneddon Trevor D. Burt James M. Gardner Chun J. Ye Mark S. Anderson Audrey V. Parent Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
description	The thymus supports T cell immunity by providing the environment for thymocyte differentiation. Here the authors profile human thymic stroma at the single cell level, identifying ionocytes as a new medullary population and defining tissue specific antigen expression in multiple stromal cell types.
format	article
author	Jhoanne L. Bautista Nathan T. Cramer Corey N. Miller Jessica Chavez David I. Berrios Lauren E. Byrnes Joe Germino Vasilis Ntranos Julie B. Sneddon Trevor D. Burt James M. Gardner Chun J. Ye Mark S. Anderson Audrey V. Parent
author_facet	Jhoanne L. Bautista Nathan T. Cramer Corey N. Miller Jessica Chavez David I. Berrios Lauren E. Byrnes Joe Germino Vasilis Ntranos Julie B. Sneddon Trevor D. Burt James M. Gardner Chun J. Ye Mark S. Anderson Audrey V. Parent
author_sort	Jhoanne L. Bautista
title	Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
title_short	Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
title_full	Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
title_fullStr	Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
title_full_unstemmed	Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
title_sort	single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c3cfdba2df144faad4bed7327a4f1bd
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

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