Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on...

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Autores principales:	Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jörg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stölting, Ute Scholl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c3f88638ed74e3884f98fb595b7139e
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spelling	oai:doaj.org-article:3c3f88638ed74e3884f98fb595b7139e2021-12-02T14:35:37ZElevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation10.1038/s41467-019-13033-42041-1723https://doaj.org/article/3c3f88638ed74e3884f98fb595b7139e2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13033-4https://doaj.org/toc/2041-1723Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.Julia ScheweEric SeidelSofia ForslundLajos MarkoJörg PetersDominik N. MullerChristoph FahlkeGabriel StöltingUte SchollNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Schewe Eric Seidel Sofia Forslund Lajos Marko Jörg Peters Dominik N. Muller Christoph Fahlke Gabriel Stölting Ute Scholl Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
description	Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.
format	article
author	Julia Schewe Eric Seidel Sofia Forslund Lajos Marko Jörg Peters Dominik N. Muller Christoph Fahlke Gabriel Stölting Ute Scholl
author_facet	Julia Schewe Eric Seidel Sofia Forslund Lajos Marko Jörg Peters Dominik N. Muller Christoph Fahlke Gabriel Stölting Ute Scholl
author_sort	Julia Schewe
title	Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
title_short	Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
title_full	Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
title_fullStr	Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
title_full_unstemmed	Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
title_sort	elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with clc-2 mutation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3c3f88638ed74e3884f98fb595b7139e
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Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

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