Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications

Abstract Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrop...

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Autores principales:	Maizlinda I. Idris, Jan Zaloga, Rainer Detsch, Judith A. Roether, Harald Unterweger, Christoph Alexiou, Aldo R. Boccaccini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c427aa4008e43e18f10247c3542e084
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spelling	oai:doaj.org-article:3c427aa4008e43e18f10247c3542e0842021-12-02T11:40:36ZSurface Modification of SPIONs in PHBV Microspheres for Biomedical Applications10.1038/s41598-018-25243-92045-2322https://doaj.org/article/3c427aa4008e43e18f10247c3542e0842018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25243-9https://doaj.org/toc/2045-2322Abstract Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. The prepared magnetic PHBV microspheres exhibited particle sizes <1 µm. The presence of functional groups of lauric acid, oleic acid and iron oxide in the PHBV microspheres was confirmed by Fourier Transform Infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis was performed to further confirm the success of the combination of modified SPIONs and PHBV. Thermogravimetric analysis (TGA) indicated that PHBV microspheres were incorporated with SPIONsLauric as compared with SPIONsOleic. This was also proven via magnetic susceptibility measurement as a higher value of this magnetic property was detected for PHBV/SPIONsLauric microspheres. It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications.Maizlinda I. IdrisJan ZalogaRainer DetschJudith A. RoetherHarald UnterwegerChristoph AlexiouAldo R. BoccacciniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maizlinda I. Idris Jan Zaloga Rainer Detsch Judith A. Roether Harald Unterweger Christoph Alexiou Aldo R. Boccaccini Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
description	Abstract Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. The prepared magnetic PHBV microspheres exhibited particle sizes <1 µm. The presence of functional groups of lauric acid, oleic acid and iron oxide in the PHBV microspheres was confirmed by Fourier Transform Infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis was performed to further confirm the success of the combination of modified SPIONs and PHBV. Thermogravimetric analysis (TGA) indicated that PHBV microspheres were incorporated with SPIONsLauric as compared with SPIONsOleic. This was also proven via magnetic susceptibility measurement as a higher value of this magnetic property was detected for PHBV/SPIONsLauric microspheres. It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications.
format	article
author	Maizlinda I. Idris Jan Zaloga Rainer Detsch Judith A. Roether Harald Unterweger Christoph Alexiou Aldo R. Boccaccini
author_facet	Maizlinda I. Idris Jan Zaloga Rainer Detsch Judith A. Roether Harald Unterweger Christoph Alexiou Aldo R. Boccaccini
author_sort	Maizlinda I. Idris
title	Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
title_short	Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
title_full	Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
title_fullStr	Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
title_full_unstemmed	Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
title_sort	surface modification of spions in phbv microspheres for biomedical applications
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c427aa4008e43e18f10247c3542e084
work_keys_str_mv	AT maizlindaiidris surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT janzaloga surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT rainerdetsch surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT juditharoether surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT haraldunterweger surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT christophalexiou surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications AT aldorboccaccini surfacemodificationofspionsinphbvmicrospheresforbiomedicalapplications
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Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications

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