Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling

The fabrication of tissue-engineered vascular grafts to replace damaged vessels is a promising therapy for cardiovascular diseases. Endothelial remodeling in the lumen of TEVGs is critical for successful revascularization. However, the construction of well-functioning TEVGs remains a fundamental cha...

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Autores principales:	Benlin Sun, Lei Hou, Binbin Sun, Yu Han, Yunqing Zou, Juexin Huang, Yanan Zhang, Chuanliang Feng, Xiaoqiu Dou, Feng Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tissue-engineered vascular graft scaffold electrospinning chirality endothelial remodeling Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/3c481c017b2c47f59a8dbaf96425bca9
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spelling	oai:doaj.org-article:3c481c017b2c47f59a8dbaf96425bca92021-12-01T01:23:45ZUse of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling2296-418510.3389/fbioe.2021.773635https://doaj.org/article/3c481c017b2c47f59a8dbaf96425bca92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.773635/fullhttps://doaj.org/toc/2296-4185The fabrication of tissue-engineered vascular grafts to replace damaged vessels is a promising therapy for cardiovascular diseases. Endothelial remodeling in the lumen of TEVGs is critical for successful revascularization. However, the construction of well-functioning TEVGs remains a fundamental challenge. Herein, chiral hybrid scaffolds were prepared by electrospinning using D/L-phenylalanine based gelators [D(L)PHEG] and poly-ε-caprolactone (PCL). The chirality of scaffolds significantly affected the endothelial remodeling progress of TEVGs. Compared with L-phenylalanine based gelators/poly-ε-caprolactone (L/PCL) and PCL, D-phenylalanine based gelators/poly-ε-caprolactone (D/PCL) scaffolds enhanced cell adhesion, and proliferation and upregulated the expression of fibronectin-1, and vinculin. These results suggests that chiral hybrid scaffolds can promote endothelial remodeling of TEVGs by upregulating adhesion-associated protein levels. This study offers an innovative strategy for endothelial remodeling of TEVGs by fabricating chiral hybrid scaffolds, and provides new insight for the treatment of cardiovascular diseases.Benlin SunLei HouBinbin SunBinbin SunYu HanYu HanYunqing ZouJuexin HuangYanan ZhangChuanliang FengXiaoqiu DouFeng XuFeng XuFrontiers Media S.A.articletissue-engineered vascular graftscaffoldelectrospinningchiralityendothelial remodelingBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue-engineered vascular graft scaffold electrospinning chirality endothelial remodeling Biotechnology TP248.13-248.65
spellingShingle	tissue-engineered vascular graft scaffold electrospinning chirality endothelial remodeling Biotechnology TP248.13-248.65 Benlin Sun Lei Hou Binbin Sun Binbin Sun Yu Han Yu Han Yunqing Zou Juexin Huang Yanan Zhang Chuanliang Feng Xiaoqiu Dou Feng Xu Feng Xu Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
description	The fabrication of tissue-engineered vascular grafts to replace damaged vessels is a promising therapy for cardiovascular diseases. Endothelial remodeling in the lumen of TEVGs is critical for successful revascularization. However, the construction of well-functioning TEVGs remains a fundamental challenge. Herein, chiral hybrid scaffolds were prepared by electrospinning using D/L-phenylalanine based gelators [D(L)PHEG] and poly-ε-caprolactone (PCL). The chirality of scaffolds significantly affected the endothelial remodeling progress of TEVGs. Compared with L-phenylalanine based gelators/poly-ε-caprolactone (L/PCL) and PCL, D-phenylalanine based gelators/poly-ε-caprolactone (D/PCL) scaffolds enhanced cell adhesion, and proliferation and upregulated the expression of fibronectin-1, and vinculin. These results suggests that chiral hybrid scaffolds can promote endothelial remodeling of TEVGs by upregulating adhesion-associated protein levels. This study offers an innovative strategy for endothelial remodeling of TEVGs by fabricating chiral hybrid scaffolds, and provides new insight for the treatment of cardiovascular diseases.
format	article
author	Benlin Sun Lei Hou Binbin Sun Binbin Sun Yu Han Yu Han Yunqing Zou Juexin Huang Yanan Zhang Chuanliang Feng Xiaoqiu Dou Feng Xu Feng Xu
author_facet	Benlin Sun Lei Hou Binbin Sun Binbin Sun Yu Han Yu Han Yunqing Zou Juexin Huang Yanan Zhang Chuanliang Feng Xiaoqiu Dou Feng Xu Feng Xu
author_sort	Benlin Sun
title	Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
title_short	Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
title_full	Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
title_fullStr	Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
title_full_unstemmed	Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling
title_sort	use of electrospun phenylalanine/poly-ε-caprolactone chiral hybrid scaffolds to promote endothelial remodeling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3c481c017b2c47f59a8dbaf96425bca9
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Use of Electrospun Phenylalanine/Poly-ε-Caprolactone Chiral Hybrid Scaffolds to Promote Endothelial Remodeling

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