Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

Lysyl oxidase-like 2 (LOXL2) is an enzyme that promotes scaffolding of extracellular matrix proteins. Here the authors show that LOXL2 is crucial for pressure-overload induced cardiac fibrosis, and that antibody-mediated inhibition or genetic disruption ofLoxl2in mice shows therapeutic potential for...

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Autores principales:	Jin Yang, Konstantinos Savvatis, Jong Seok Kang, Peidong Fan, Hongyan Zhong, Karen Schwartz, Vivian Barry, Amanda Mikels-Vigdal, Serge Karpinski, Dmytro Kornyeyev, Joanne Adamkewicz, Xuhui Feng, Qiong Zhou, Ching Shang, Praveen Kumar, Dillon Phan, Mario Kasner, Begoña López, Javier Diez, Keith C. Wright, Roxanne L. Kovacs, Peng-Sheng Chen, Thomas Quertermous, Victoria Smith, Lina Yao, Carsten Tschöpe, Ching-Pin Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c49e4174d5d4829a56a0c196d697c78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3c49e4174d5d4829a56a0c196d697c782021-12-02T17:31:34ZTargeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment10.1038/ncomms137102041-1723https://doaj.org/article/3c49e4174d5d4829a56a0c196d697c782016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13710https://doaj.org/toc/2041-1723Lysyl oxidase-like 2 (LOXL2) is an enzyme that promotes scaffolding of extracellular matrix proteins. Here the authors show that LOXL2 is crucial for pressure-overload induced cardiac fibrosis, and that antibody-mediated inhibition or genetic disruption ofLoxl2in mice shows therapeutic potential for treatment of cardiac fibrosis.Jin YangKonstantinos SavvatisJong Seok KangPeidong FanHongyan ZhongKaren SchwartzVivian BarryAmanda Mikels-VigdalSerge KarpinskiDmytro KornyeyevJoanne AdamkewiczXuhui FengQiong ZhouChing ShangPraveen KumarDillon PhanMario KasnerBegoña LópezJavier DiezKeith C. WrightRoxanne L. KovacsPeng-Sheng ChenThomas QuertermousVictoria SmithLina YaoCarsten TschöpeChing-Pin ChangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Yang Konstantinos Savvatis Jong Seok Kang Peidong Fan Hongyan Zhong Karen Schwartz Vivian Barry Amanda Mikels-Vigdal Serge Karpinski Dmytro Kornyeyev Joanne Adamkewicz Xuhui Feng Qiong Zhou Ching Shang Praveen Kumar Dillon Phan Mario Kasner Begoña López Javier Diez Keith C. Wright Roxanne L. Kovacs Peng-Sheng Chen Thomas Quertermous Victoria Smith Lina Yao Carsten Tschöpe Ching-Pin Chang Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
description	Lysyl oxidase-like 2 (LOXL2) is an enzyme that promotes scaffolding of extracellular matrix proteins. Here the authors show that LOXL2 is crucial for pressure-overload induced cardiac fibrosis, and that antibody-mediated inhibition or genetic disruption ofLoxl2in mice shows therapeutic potential for treatment of cardiac fibrosis.
format	article
author	Jin Yang Konstantinos Savvatis Jong Seok Kang Peidong Fan Hongyan Zhong Karen Schwartz Vivian Barry Amanda Mikels-Vigdal Serge Karpinski Dmytro Kornyeyev Joanne Adamkewicz Xuhui Feng Qiong Zhou Ching Shang Praveen Kumar Dillon Phan Mario Kasner Begoña López Javier Diez Keith C. Wright Roxanne L. Kovacs Peng-Sheng Chen Thomas Quertermous Victoria Smith Lina Yao Carsten Tschöpe Ching-Pin Chang
author_facet	Jin Yang Konstantinos Savvatis Jong Seok Kang Peidong Fan Hongyan Zhong Karen Schwartz Vivian Barry Amanda Mikels-Vigdal Serge Karpinski Dmytro Kornyeyev Joanne Adamkewicz Xuhui Feng Qiong Zhou Ching Shang Praveen Kumar Dillon Phan Mario Kasner Begoña López Javier Diez Keith C. Wright Roxanne L. Kovacs Peng-Sheng Chen Thomas Quertermous Victoria Smith Lina Yao Carsten Tschöpe Ching-Pin Chang
author_sort	Jin Yang
title	Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
title_short	Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
title_full	Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
title_fullStr	Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
title_full_unstemmed	Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
title_sort	targeting loxl2 for cardiac interstitial fibrosis and heart failure treatment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3c49e4174d5d4829a56a0c196d697c78
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Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

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