Impact of a single bout of resistance exercise on serum Klotho in healthy young men

Abstract Background It has been shown that Klotho protects vascular endothelial function. Given that a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial dysfunction, we postulated that acute resistance exercise would reduce serum Klotho levels. In this respect, the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takuma Morishima, Eisuke Ochi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	endothelial function endothelin‐1 resistance exercise flow‐mediated dilation Klotho Physiology QP1-981
Acceso en línea:	https://doaj.org/article/3c4a0f9b53d74734b7f873d8665ff7d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c4a0f9b53d74734b7f873d8665ff7d5
record_format	dspace
spelling	oai:doaj.org-article:3c4a0f9b53d74734b7f873d8665ff7d52021-11-15T09:54:40ZImpact of a single bout of resistance exercise on serum Klotho in healthy young men2051-817X10.14814/phy2.15087https://doaj.org/article/3c4a0f9b53d74734b7f873d8665ff7d52021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15087https://doaj.org/toc/2051-817XAbstract Background It has been shown that Klotho protects vascular endothelial function. Given that a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial dysfunction, we postulated that acute resistance exercise would reduce serum Klotho levels. In this respect, the reduction in serum Klotho levels would be associated with the response of flow‐mediated dilation (FMD). Therefore, the purpose of this study was to investigate the impact of acute resistance exercise on the Klotho response in serum. In addition, we examined the relationship between the serum Klotho and FMD responses following acute resistance exercise. Methods Twelve untrained men participated in this study (20.4 ± 0.3 years). Following baseline measurements (blood pressure, blood collection, FMD), subjects performed leg extensions, which consisted of 10 repetitions for five sets at 70% of one‐repetition maximum. After the exercise, measurement of blood pressure, blood collection, and FMD assessment were repeated for 60 min. We analyzed Klotho and endothelin‐1 (ET‐1) concentrations in blood serum. Results As expected, the exercise significantly elevated blood pressure and led to decreased FMD (p < 0.05). However, Klotho concentrations were significantly increased following exercise (p < 0.05). No correlation was observed in Klotho and FMD responses following acute resistance exercise. However, there was a significant positive correlation between Klotho and ET‐1 in response to resistance exercise (p < 0.05). Conclusion In conclusion, the present study reveals that serum Klotho significantly increased following a single bout of resistance exercise. However, the increase in Klotho may not associate with the acute reduction in endothelial function.Takuma MorishimaEisuke OchiWileyarticleendothelial functionendothelin‐1 resistance exerciseflow‐mediated dilationKlothoPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endothelial function endothelin‐1 resistance exercise flow‐mediated dilation Klotho Physiology QP1-981
spellingShingle	endothelial function endothelin‐1 resistance exercise flow‐mediated dilation Klotho Physiology QP1-981 Takuma Morishima Eisuke Ochi Impact of a single bout of resistance exercise on serum Klotho in healthy young men
description	Abstract Background It has been shown that Klotho protects vascular endothelial function. Given that a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial dysfunction, we postulated that acute resistance exercise would reduce serum Klotho levels. In this respect, the reduction in serum Klotho levels would be associated with the response of flow‐mediated dilation (FMD). Therefore, the purpose of this study was to investigate the impact of acute resistance exercise on the Klotho response in serum. In addition, we examined the relationship between the serum Klotho and FMD responses following acute resistance exercise. Methods Twelve untrained men participated in this study (20.4 ± 0.3 years). Following baseline measurements (blood pressure, blood collection, FMD), subjects performed leg extensions, which consisted of 10 repetitions for five sets at 70% of one‐repetition maximum. After the exercise, measurement of blood pressure, blood collection, and FMD assessment were repeated for 60 min. We analyzed Klotho and endothelin‐1 (ET‐1) concentrations in blood serum. Results As expected, the exercise significantly elevated blood pressure and led to decreased FMD (p < 0.05). However, Klotho concentrations were significantly increased following exercise (p < 0.05). No correlation was observed in Klotho and FMD responses following acute resistance exercise. However, there was a significant positive correlation between Klotho and ET‐1 in response to resistance exercise (p < 0.05). Conclusion In conclusion, the present study reveals that serum Klotho significantly increased following a single bout of resistance exercise. However, the increase in Klotho may not associate with the acute reduction in endothelial function.
format	article
author	Takuma Morishima Eisuke Ochi
author_facet	Takuma Morishima Eisuke Ochi
author_sort	Takuma Morishima
title	Impact of a single bout of resistance exercise on serum Klotho in healthy young men
title_short	Impact of a single bout of resistance exercise on serum Klotho in healthy young men
title_full	Impact of a single bout of resistance exercise on serum Klotho in healthy young men
title_fullStr	Impact of a single bout of resistance exercise on serum Klotho in healthy young men
title_full_unstemmed	Impact of a single bout of resistance exercise on serum Klotho in healthy young men
title_sort	impact of a single bout of resistance exercise on serum klotho in healthy young men
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/3c4a0f9b53d74734b7f873d8665ff7d5
work_keys_str_mv	AT takumamorishima impactofasingleboutofresistanceexerciseonserumklothoinhealthyyoungmen AT eisukeochi impactofasingleboutofresistanceexerciseonserumklothoinhealthyyoungmen
_version_	1718428427982209024

Impact of a single bout of resistance exercise on serum Klotho in healthy young men

Ejemplares similares