Chagas Disease and Heart Failure: An Expanding Issue Worldwide

Chagas disease, originally a South American endemic health problem, is expanding worldwide because of people migration. Its main impact is on the cardiovascular system, producing myocardial damage that frequently results in heart failure. Pathogenic pathways are mainly related to inmunoinflamatory r...

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Autores principales:	Felipe Martinez, Eduardo Perna, Sergio V Perrone, Alvaro Sosa Liprandi
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3c4cca618885462184b4cb15bef4ff6b
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spelling	oai:doaj.org-article:3c4cca618885462184b4cb15bef4ff6b2021-12-04T16:01:30ZChagas Disease and Heart Failure: An Expanding Issue Worldwide10.15420/ecr.2018.30.21758-37641758-3756https://doaj.org/article/3c4cca618885462184b4cb15bef4ff6b2019-07-01T00:00:00Zhttps://www.ecrjournal.com/articles/chagas-disease-heart-failure-issue-worldwidehttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Chagas disease, originally a South American endemic health problem, is expanding worldwide because of people migration. Its main impact is on the cardiovascular system, producing myocardial damage that frequently results in heart failure. Pathogenic pathways are mainly related to inmunoinflamatory reactions in the myocardium and, less frequently, in the gastrointestinal tract. The heart usually shows fibrosis, producing dilatation and damage of the electrogenic cardiac system. These changes result in cardiomyopathy with heart failure and frequent cardiac arrhythmias and heart blocks. Diagnosis of the disease must include a lab test to detect the parasite or its immune reactions and the usual techniques to evaluate cardiac function. Therapeutic management of Chagas heart failure does not differ significantly from the most common treatment for dilated cardiomyopathy, with special focus on arrhythmias and several degrees of heart block. Heart transplantation is reserved for end-stage cases. Major international scientific organisations are delivering recommendations for prevention and early diagnosis. This article provides an analysis of epidemiology, prevention, treatment and the relationship between Chagas disease and heart failure.Felipe MartinezEduardo PernaSergio V PerroneAlvaro Sosa LiprandiRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 2, Pp 82-88 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Felipe Martinez Eduardo Perna Sergio V Perrone Alvaro Sosa Liprandi Chagas Disease and Heart Failure: An Expanding Issue Worldwide
description	Chagas disease, originally a South American endemic health problem, is expanding worldwide because of people migration. Its main impact is on the cardiovascular system, producing myocardial damage that frequently results in heart failure. Pathogenic pathways are mainly related to inmunoinflamatory reactions in the myocardium and, less frequently, in the gastrointestinal tract. The heart usually shows fibrosis, producing dilatation and damage of the electrogenic cardiac system. These changes result in cardiomyopathy with heart failure and frequent cardiac arrhythmias and heart blocks. Diagnosis of the disease must include a lab test to detect the parasite or its immune reactions and the usual techniques to evaluate cardiac function. Therapeutic management of Chagas heart failure does not differ significantly from the most common treatment for dilated cardiomyopathy, with special focus on arrhythmias and several degrees of heart block. Heart transplantation is reserved for end-stage cases. Major international scientific organisations are delivering recommendations for prevention and early diagnosis. This article provides an analysis of epidemiology, prevention, treatment and the relationship between Chagas disease and heart failure.
format	article
author	Felipe Martinez Eduardo Perna Sergio V Perrone Alvaro Sosa Liprandi
author_facet	Felipe Martinez Eduardo Perna Sergio V Perrone Alvaro Sosa Liprandi
author_sort	Felipe Martinez
title	Chagas Disease and Heart Failure: An Expanding Issue Worldwide
title_short	Chagas Disease and Heart Failure: An Expanding Issue Worldwide
title_full	Chagas Disease and Heart Failure: An Expanding Issue Worldwide
title_fullStr	Chagas Disease and Heart Failure: An Expanding Issue Worldwide
title_full_unstemmed	Chagas Disease and Heart Failure: An Expanding Issue Worldwide
title_sort	chagas disease and heart failure: an expanding issue worldwide
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/3c4cca618885462184b4cb15bef4ff6b
work_keys_str_mv	AT felipemartinez chagasdiseaseandheartfailureanexpandingissueworldwide AT eduardoperna chagasdiseaseandheartfailureanexpandingissueworldwide AT sergiovperrone chagasdiseaseandheartfailureanexpandingissueworldwide AT alvarososaliprandi chagasdiseaseandheartfailureanexpandingissueworldwide
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Chagas Disease and Heart Failure: An Expanding Issue Worldwide

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