Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila

Formaldehyde (FA) is a commercially important chemical applied in industry and scientific research. However, FA has a distinct impact on learning and memory. Although the mechanisms of FA toxicity have been well studied, additional research is required to establish the mechanisms of neuroprotection...

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Autores principales:	Hua Yanli, Ma Chao, Huang Shuyi, Wang Ruomeng, Chen Jian, Guo Qing, Zhou Jiaojiao, Zhu Hemin, Li Wenjie
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	formaldehyde docosahexaenoic acid neuroprotection Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3c4e061d3bdf4366bfb004ea9c867b33
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id	oai:doaj.org-article:3c4e061d3bdf4366bfb004ea9c867b33
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spelling	oai:doaj.org-article:3c4e061d3bdf4366bfb004ea9c867b332021-12-05T14:11:05ZToxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila2081-693610.1515/tnsci-2020-0186https://doaj.org/article/3c4e061d3bdf4366bfb004ea9c867b332021-10-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0186https://doaj.org/toc/2081-6936Formaldehyde (FA) is a commercially important chemical applied in industry and scientific research. However, FA has a distinct impact on learning and memory. Although the mechanisms of FA toxicity have been well studied, additional research is required to establish the mechanisms of neuroprotection in cases of FA exposure. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid with a variety of health benefits, including the enhancement of learning and memory. In this study, we investigated the neuroprotective effects of DHA in Drosophila melanogaster that had ingested FA. Our data suggested that DHA enhanced reproductive processes, leading to an increase in the number of eggs, larvae, and adults. Surprisingly, we found that DHA had a mild protective effect against FA-induced impairments in learning and memory.Hua YanliMa ChaoHuang ShuyiWang RuomengChen JianGuo QingZhou JiaojiaoZhu HeminLi WenjieDe Gruyterarticleformaldehydedocosahexaenoic acidneuroprotectionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 351-361 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	formaldehyde docosahexaenoic acid neuroprotection Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	formaldehyde docosahexaenoic acid neuroprotection Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hua Yanli Ma Chao Huang Shuyi Wang Ruomeng Chen Jian Guo Qing Zhou Jiaojiao Zhu Hemin Li Wenjie Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
description	Formaldehyde (FA) is a commercially important chemical applied in industry and scientific research. However, FA has a distinct impact on learning and memory. Although the mechanisms of FA toxicity have been well studied, additional research is required to establish the mechanisms of neuroprotection in cases of FA exposure. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid with a variety of health benefits, including the enhancement of learning and memory. In this study, we investigated the neuroprotective effects of DHA in Drosophila melanogaster that had ingested FA. Our data suggested that DHA enhanced reproductive processes, leading to an increase in the number of eggs, larvae, and adults. Surprisingly, we found that DHA had a mild protective effect against FA-induced impairments in learning and memory.
format	article
author	Hua Yanli Ma Chao Huang Shuyi Wang Ruomeng Chen Jian Guo Qing Zhou Jiaojiao Zhu Hemin Li Wenjie
author_facet	Hua Yanli Ma Chao Huang Shuyi Wang Ruomeng Chen Jian Guo Qing Zhou Jiaojiao Zhu Hemin Li Wenjie
author_sort	Hua Yanli
title	Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
title_short	Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
title_full	Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
title_fullStr	Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
title_full_unstemmed	Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila
title_sort	toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in drosophila
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/3c4e061d3bdf4366bfb004ea9c867b33
work_keys_str_mv	AT huayanli toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT machao toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT huangshuyi toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT wangruomeng toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT chenjian toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT guoqing toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT zhoujiaojiao toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT zhuhemin toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila AT liwenjie toxiceffectsofformaldehydeandtheprotectiveeffectofdocosahexaenoicacidindrosophila
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Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila

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