Retinal vessels modifications in acute and post-COVID-19

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study inves...

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Autores principales:	Alessandro Invernizzi, Marco Schiuma, Salvatore Parrulli, Alessandro Torre, Federico Zicarelli, Valeria Colombo, Sara Marini, Elena Villella, Alice Bertoni, Spinello Antinori, Giuliano Rizzardini, Massimo Galli, Luca Meroni, Andrea Giacomelli, Giovanni Staurenghi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c4ec8d0fd8544e99dbd01027a0ff4a2
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spelling	oai:doaj.org-article:3c4ec8d0fd8544e99dbd01027a0ff4a22021-12-02T19:17:04ZRetinal vessels modifications in acute and post-COVID-1910.1038/s41598-021-98873-12045-2322https://doaj.org/article/3c4ec8d0fd8544e99dbd01027a0ff4a22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98873-1https://doaj.org/toc/2045-2322Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 ± 10.9 to 92.2 ± 11.4 µm, p < 0.0001 and from 133.1 ± 19.3 to 124.6 ± 16.1 µm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function.Alessandro InvernizziMarco SchiumaSalvatore ParrulliAlessandro TorreFederico ZicarelliValeria ColomboSara MariniElena VillellaAlice BertoniSpinello AntinoriGiuliano RizzardiniMassimo GalliLuca MeroniAndrea GiacomelliGiovanni StaurenghiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandro Invernizzi Marco Schiuma Salvatore Parrulli Alessandro Torre Federico Zicarelli Valeria Colombo Sara Marini Elena Villella Alice Bertoni Spinello Antinori Giuliano Rizzardini Massimo Galli Luca Meroni Andrea Giacomelli Giovanni Staurenghi Retinal vessels modifications in acute and post-COVID-19
description	Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 ± 10.9 to 92.2 ± 11.4 µm, p < 0.0001 and from 133.1 ± 19.3 to 124.6 ± 16.1 µm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function.
format	article
author	Alessandro Invernizzi Marco Schiuma Salvatore Parrulli Alessandro Torre Federico Zicarelli Valeria Colombo Sara Marini Elena Villella Alice Bertoni Spinello Antinori Giuliano Rizzardini Massimo Galli Luca Meroni Andrea Giacomelli Giovanni Staurenghi
author_facet	Alessandro Invernizzi Marco Schiuma Salvatore Parrulli Alessandro Torre Federico Zicarelli Valeria Colombo Sara Marini Elena Villella Alice Bertoni Spinello Antinori Giuliano Rizzardini Massimo Galli Luca Meroni Andrea Giacomelli Giovanni Staurenghi
author_sort	Alessandro Invernizzi
title	Retinal vessels modifications in acute and post-COVID-19
title_short	Retinal vessels modifications in acute and post-COVID-19
title_full	Retinal vessels modifications in acute and post-COVID-19
title_fullStr	Retinal vessels modifications in acute and post-COVID-19
title_full_unstemmed	Retinal vessels modifications in acute and post-COVID-19
title_sort	retinal vessels modifications in acute and post-covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c4ec8d0fd8544e99dbd01027a0ff4a2
work_keys_str_mv	AT alessandroinvernizzi retinalvesselsmodificationsinacuteandpostcovid19 AT marcoschiuma retinalvesselsmodificationsinacuteandpostcovid19 AT salvatoreparrulli retinalvesselsmodificationsinacuteandpostcovid19 AT alessandrotorre retinalvesselsmodificationsinacuteandpostcovid19 AT federicozicarelli retinalvesselsmodificationsinacuteandpostcovid19 AT valeriacolombo retinalvesselsmodificationsinacuteandpostcovid19 AT saramarini retinalvesselsmodificationsinacuteandpostcovid19 AT elenavillella retinalvesselsmodificationsinacuteandpostcovid19 AT alicebertoni retinalvesselsmodificationsinacuteandpostcovid19 AT spinelloantinori retinalvesselsmodificationsinacuteandpostcovid19 AT giulianorizzardini retinalvesselsmodificationsinacuteandpostcovid19 AT massimogalli retinalvesselsmodificationsinacuteandpostcovid19 AT lucameroni retinalvesselsmodificationsinacuteandpostcovid19 AT andreagiacomelli retinalvesselsmodificationsinacuteandpostcovid19 AT giovannistaurenghi retinalvesselsmodificationsinacuteandpostcovid19
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Retinal vessels modifications in acute and post-COVID-19

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