A comprehensive analysis of prefoldins and their implication in cancer

Summary: Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero-hexameric complexes. Although they have been overlooked since their discovery and their functions remain elusive, s...

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Autores principales:	Irene Herranz-Montoya, Solip Park, Nabil Djouder
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Cell biology Cancer Science Q
Acceso en línea:	https://doaj.org/article/3c4ed118909c47a88ceac3d61f2308f7
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spelling	oai:doaj.org-article:3c4ed118909c47a88ceac3d61f2308f72021-11-20T05:09:09ZA comprehensive analysis of prefoldins and their implication in cancer2589-004210.1016/j.isci.2021.103273https://doaj.org/article/3c4ed118909c47a88ceac3d61f2308f72021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012426https://doaj.org/toc/2589-0042Summary: Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero-hexameric complexes. Although they have been overlooked since their discovery and their functions remain elusive, several reports indicate they act as co-chaperones escorting misfolded or non-native proteins to group II chaperonins. Unlike the eukaryotic PFDNs which interact with cytoskeletal components, the archaeal PFDNs can bind and stabilize a wide range of substrates, possibly due to their great structural diversity. The discovery of the unconventional RPB5 interactor (URI) PFDN-like complex (UPC) suggests that PFDNs have versatile functions and are required for different cellular processes, including an important role in cancer. Here, we summarize their functions across different species. Moreover, a comprehensive analysis of PFDNs genomic alterations across cancer types by using large-scale cancer genomic data indicates that PFDNs are a new class of non-mutated proteins significantly overexpressed in some cancer types.Irene Herranz-MontoyaSolip ParkNabil DjouderElsevierarticleBiological sciencesCell biologyCancerScienceQENiScience, Vol 24, Iss 11, Pp 103273- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Cell biology Cancer Science Q
spellingShingle	Biological sciences Cell biology Cancer Science Q Irene Herranz-Montoya Solip Park Nabil Djouder A comprehensive analysis of prefoldins and their implication in cancer
description	Summary: Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero-hexameric complexes. Although they have been overlooked since their discovery and their functions remain elusive, several reports indicate they act as co-chaperones escorting misfolded or non-native proteins to group II chaperonins. Unlike the eukaryotic PFDNs which interact with cytoskeletal components, the archaeal PFDNs can bind and stabilize a wide range of substrates, possibly due to their great structural diversity. The discovery of the unconventional RPB5 interactor (URI) PFDN-like complex (UPC) suggests that PFDNs have versatile functions and are required for different cellular processes, including an important role in cancer. Here, we summarize their functions across different species. Moreover, a comprehensive analysis of PFDNs genomic alterations across cancer types by using large-scale cancer genomic data indicates that PFDNs are a new class of non-mutated proteins significantly overexpressed in some cancer types.
format	article
author	Irene Herranz-Montoya Solip Park Nabil Djouder
author_facet	Irene Herranz-Montoya Solip Park Nabil Djouder
author_sort	Irene Herranz-Montoya
title	A comprehensive analysis of prefoldins and their implication in cancer
title_short	A comprehensive analysis of prefoldins and their implication in cancer
title_full	A comprehensive analysis of prefoldins and their implication in cancer
title_fullStr	A comprehensive analysis of prefoldins and their implication in cancer
title_full_unstemmed	A comprehensive analysis of prefoldins and their implication in cancer
title_sort	comprehensive analysis of prefoldins and their implication in cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3c4ed118909c47a88ceac3d61f2308f7
work_keys_str_mv	AT ireneherranzmontoya acomprehensiveanalysisofprefoldinsandtheirimplicationincancer AT solippark acomprehensiveanalysisofprefoldinsandtheirimplicationincancer AT nabildjouder acomprehensiveanalysisofprefoldinsandtheirimplicationincancer AT ireneherranzmontoya comprehensiveanalysisofprefoldinsandtheirimplicationincancer AT solippark comprehensiveanalysisofprefoldinsandtheirimplicationincancer AT nabildjouder comprehensiveanalysisofprefoldinsandtheirimplicationincancer
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A comprehensive analysis of prefoldins and their implication in cancer

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