Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study

Abstract The purpose of this prospective, case control study was to investigate the differences in optic nerve head blood flow measured with Laser Speckle Flowgraphy (LSFG) between Caucasian patients with normal tension glaucoma and healthy subjects. It included 20 eyes from 20 Caucasian patients wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer, Matthias Bolz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c51ad38ff4f48baaabf36c848ad7547
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c51ad38ff4f48baaabf36c848ad7547
record_format	dspace
spelling	oai:doaj.org-article:3c51ad38ff4f48baaabf36c848ad75472021-12-02T15:07:58ZLaser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study10.1038/s41598-018-23149-02045-2322https://doaj.org/article/3c51ad38ff4f48baaabf36c848ad75472018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23149-0https://doaj.org/toc/2045-2322Abstract The purpose of this prospective, case control study was to investigate the differences in optic nerve head blood flow measured with Laser Speckle Flowgraphy (LSFG) between Caucasian patients with normal tension glaucoma and healthy subjects. It included 20 eyes from 20 Caucasian patients with diagnosis of normal tension glaucoma and 20 eyes from age- and sex-matched healthy individuals. In the glaucoma group the antiglaucomatous therapy was paused 3 weeks prior to the investigations. Measurement of optic nerve head blood flow was performed with LSFG. The mean blur rate was obtained for different vascular compartments of the optic nerve head. Parameters for the characterization of pulse-waveform of the mean blur rate were calculated. It was shown that the mean blur rate was significantly lower in the glaucoma group compared to the control group (P < 0.001). The significant differences in the pulse-waveform parameters blow out time (P = 0.028) and flow acceleration time index (P < 0.001) indicate a flatter curve in NTG patients. In conclusion, LSFG can detect differences in optic nerve head blood flow between eyes with normal tension glaucoma and healthy eyes.Anna Sophie Mursch-EdlmayrNikolaus LuftDominika PodkowinskiMichael RingLeopold SchmettererMatthias BolzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Sophie Mursch-Edlmayr Nikolaus Luft Dominika Podkowinski Michael Ring Leopold Schmetterer Matthias Bolz Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
description	Abstract The purpose of this prospective, case control study was to investigate the differences in optic nerve head blood flow measured with Laser Speckle Flowgraphy (LSFG) between Caucasian patients with normal tension glaucoma and healthy subjects. It included 20 eyes from 20 Caucasian patients with diagnosis of normal tension glaucoma and 20 eyes from age- and sex-matched healthy individuals. In the glaucoma group the antiglaucomatous therapy was paused 3 weeks prior to the investigations. Measurement of optic nerve head blood flow was performed with LSFG. The mean blur rate was obtained for different vascular compartments of the optic nerve head. Parameters for the characterization of pulse-waveform of the mean blur rate were calculated. It was shown that the mean blur rate was significantly lower in the glaucoma group compared to the control group (P < 0.001). The significant differences in the pulse-waveform parameters blow out time (P = 0.028) and flow acceleration time index (P < 0.001) indicate a flatter curve in NTG patients. In conclusion, LSFG can detect differences in optic nerve head blood flow between eyes with normal tension glaucoma and healthy eyes.
format	article
author	Anna Sophie Mursch-Edlmayr Nikolaus Luft Dominika Podkowinski Michael Ring Leopold Schmetterer Matthias Bolz
author_facet	Anna Sophie Mursch-Edlmayr Nikolaus Luft Dominika Podkowinski Michael Ring Leopold Schmetterer Matthias Bolz
author_sort	Anna Sophie Mursch-Edlmayr
title	Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
title_short	Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
title_full	Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
title_fullStr	Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
title_full_unstemmed	Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study
title_sort	laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a pilot study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c51ad38ff4f48baaabf36c848ad7547
work_keys_str_mv	AT annasophiemurschedlmayr laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy AT nikolausluft laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy AT dominikapodkowinski laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy AT michaelring laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy AT leopoldschmetterer laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy AT matthiasbolz laserspeckleflowgraphyderivedcharacteristicsofopticnerveheadperfusioninnormaltensionglaucomaandhealthyindividualsapilotstudy
_version_	1718388308900315136

Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study

Ejemplares similares