Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure

Viral capsids need to protect the genome against harsh environmental conditions and cope with high internal pressure from the packaged genome. Here, the authors determine the structure of the thermostable phage P74-26 capsid at 2.8-Å resolution and identify features underlying enhanced capsid capaci...

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Autores principales: Nicholas P. Stone, Gabriel Demo, Emily Agnello, Brian A. Kelch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3c52f833affb4893b605b3ae7c48faca
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spelling oai:doaj.org-article:3c52f833affb4893b605b3ae7c48faca2021-12-02T14:39:42ZPrinciples for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure10.1038/s41467-019-12341-z2041-1723https://doaj.org/article/3c52f833affb4893b605b3ae7c48faca2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12341-zhttps://doaj.org/toc/2041-1723Viral capsids need to protect the genome against harsh environmental conditions and cope with high internal pressure from the packaged genome. Here, the authors determine the structure of the thermostable phage P74-26 capsid at 2.8-Å resolution and identify features underlying enhanced capsid capacity and structural stability.Nicholas P. StoneGabriel DemoEmily AgnelloBrian A. KelchNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicholas P. Stone
Gabriel Demo
Emily Agnello
Brian A. Kelch
Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
description Viral capsids need to protect the genome against harsh environmental conditions and cope with high internal pressure from the packaged genome. Here, the authors determine the structure of the thermostable phage P74-26 capsid at 2.8-Å resolution and identify features underlying enhanced capsid capacity and structural stability.
format article
author Nicholas P. Stone
Gabriel Demo
Emily Agnello
Brian A. Kelch
author_facet Nicholas P. Stone
Gabriel Demo
Emily Agnello
Brian A. Kelch
author_sort Nicholas P. Stone
title Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
title_short Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
title_full Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
title_fullStr Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
title_full_unstemmed Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
title_sort principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3c52f833affb4893b605b3ae7c48faca
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AT emilyagnello principlesforenhancingviruscapsidcapacityandstabilityfromathermophilicviruscapsidstructure
AT brianakelch principlesforenhancingviruscapsidcapacityandstabilityfromathermophilicviruscapsidstructure
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