Stem cell technology in breast cancer: current status and potential applications

Rena Chiotaki, Hara Polioudaki, Panayiotis A Theodoropoulos Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece Abstract: Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the t...

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Autores principales:	Chiotaki R, Polioudaki H, Theodoropoulos PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Breast cancer stem cells cancer stem cell heterogeneity targeting cancer stem cells circulating tumor cells stem cell technology Cytology QH573-671
Acceso en línea:	https://doaj.org/article/3c5800a4b3ad4ccb810a8a42323ca84c
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spelling	oai:doaj.org-article:3c5800a4b3ad4ccb810a8a42323ca84c2021-12-02T00:13:22ZStem cell technology in breast cancer: current status and potential applications1178-6957https://doaj.org/article/3c5800a4b3ad4ccb810a8a42323ca84c2016-04-01T00:00:00Zhttps://www.dovepress.com/stem-cell-technology-in-breast-cancer-current-status-and-potential-app-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Rena Chiotaki, Hara Polioudaki, Panayiotis A Theodoropoulos Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece Abstract: Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the tumor, identified as breast cancer stem cells (BCSCs). BCSCs underlie the mechanisms of tumor initiation and sustenance and are implicated in the dissemination of the primary tumor to metastatic sites, as they have been found circulating in the blood of breast cancer patients. The discovery of BCSCs has generated a great amount of interest among the scientific community toward their isolation, molecular characterization, and therapeutic targeting. In this review, after summarizing the literature on molecular characterization of BCSCs and methodologies used for their isolation, we will focus on recent data supporting their molecular and functional heterogeneity. Additionally, following a synopsis of the latest approaches for BCSC targeting, we will specifically emphasize on the therapeutic use of naïve or engineered normal stem cells in the treatment of breast cancer and present contradictory findings challenging their safety. Keywords: breast cancer stem cells, cancer stem cell heterogeneity, targeting cancer stem cells, circulating tumor cells, stem cell technologyChiotaki RPolioudaki HTheodoropoulos PADove Medical PressarticleBreast cancer stem cellscancer stem cell heterogeneitytargeting cancer stem cellscirculating tumor cellsstem cell technologyCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2016, Iss Issue 1, Pp 17-29 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer stem cells cancer stem cell heterogeneity targeting cancer stem cells circulating tumor cells stem cell technology Cytology QH573-671
spellingShingle	Breast cancer stem cells cancer stem cell heterogeneity targeting cancer stem cells circulating tumor cells stem cell technology Cytology QH573-671 Chiotaki R Polioudaki H Theodoropoulos PA Stem cell technology in breast cancer: current status and potential applications
description	Rena Chiotaki, Hara Polioudaki, Panayiotis A Theodoropoulos Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece Abstract: Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the tumor, identified as breast cancer stem cells (BCSCs). BCSCs underlie the mechanisms of tumor initiation and sustenance and are implicated in the dissemination of the primary tumor to metastatic sites, as they have been found circulating in the blood of breast cancer patients. The discovery of BCSCs has generated a great amount of interest among the scientific community toward their isolation, molecular characterization, and therapeutic targeting. In this review, after summarizing the literature on molecular characterization of BCSCs and methodologies used for their isolation, we will focus on recent data supporting their molecular and functional heterogeneity. Additionally, following a synopsis of the latest approaches for BCSC targeting, we will specifically emphasize on the therapeutic use of naïve or engineered normal stem cells in the treatment of breast cancer and present contradictory findings challenging their safety. Keywords: breast cancer stem cells, cancer stem cell heterogeneity, targeting cancer stem cells, circulating tumor cells, stem cell technology
format	article
author	Chiotaki R Polioudaki H Theodoropoulos PA
author_facet	Chiotaki R Polioudaki H Theodoropoulos PA
author_sort	Chiotaki R
title	Stem cell technology in breast cancer: current status and potential applications
title_short	Stem cell technology in breast cancer: current status and potential applications
title_full	Stem cell technology in breast cancer: current status and potential applications
title_fullStr	Stem cell technology in breast cancer: current status and potential applications
title_full_unstemmed	Stem cell technology in breast cancer: current status and potential applications
title_sort	stem cell technology in breast cancer: current status and potential applications
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/3c5800a4b3ad4ccb810a8a42323ca84c
work_keys_str_mv	AT chiotakir stemcelltechnologyinbreastcancercurrentstatusandpotentialapplications AT polioudakih stemcelltechnologyinbreastcancercurrentstatusandpotentialapplications AT theodoropoulospa stemcelltechnologyinbreastcancercurrentstatusandpotentialapplications
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Stem cell technology in breast cancer: current status and potential applications

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