Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.

<h4>Introduction</h4>Fast in-vivo high resolution diffusion tensor imaging (DTI) of the mouse brain has recently been shown to enable cohort studies by the combination of appropriate pulse sequences and cryogenically cooled resonators (CCR). The objective of this study was to apply this...

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Autores principales:	Hans-Peter Müller, Jan Kassubek, Ina Vernikouskaya, Albert C Ludolph, Detlef Stiller, Volker Rasche
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c58d5202da54fa4bffebb92a0ee4363
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spelling	oai:doaj.org-article:3c58d5202da54fa4bffebb92a0ee43632021-11-18T07:39:24ZDiffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.1932-620310.1371/journal.pone.0067630https://doaj.org/article/3c58d5202da54fa4bffebb92a0ee43632013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840754/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Fast in-vivo high resolution diffusion tensor imaging (DTI) of the mouse brain has recently been shown to enable cohort studies by the combination of appropriate pulse sequences and cryogenically cooled resonators (CCR). The objective of this study was to apply this DTI approach at the group level to β-amyloid precursor protein (APP) transgenic mice.<h4>Methods</h4>Twelve mice (5 wild type, 7 APP transgenic tg2576) underwent DTI examination at 156(2) × 250 µm(3) spatial resolution with a CCR at ultrahigh field (11.7 T). Diffusion images were acquired along 30 gradient directions plus 5 references without diffusion encoding with a total acquisition time of 35 minutes. Fractional anisotropy (FA) maps were statistically compared by whole brain-based spatial statistics (WBSS) at the group level vs. wild type controls.<h4>Results</h4>FA-map comparison showed characteristic regional patterns of differences between the groups with localizations associated with Alzheimer's disease in humans, such as the hippocampus, the entorhinal cortex, and the caudoputamen.<h4>Conclusion</h4>In this proof-of-principle study, regions associated with amyloid-β deposition could be identified by WBSS of FA maps in APP transgenic mice vs. wild type mice. Thus, DTI in the mouse brain acquired at 11.7 T by use of a CCR was demonstrated to be feasible for cohort studies.Hans-Peter MüllerJan KassubekIna VernikouskayaAlbert C LudolphDetlef StillerVolker RaschePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67630 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hans-Peter Müller Jan Kassubek Ina Vernikouskaya Albert C Ludolph Detlef Stiller Volker Rasche Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
description	<h4>Introduction</h4>Fast in-vivo high resolution diffusion tensor imaging (DTI) of the mouse brain has recently been shown to enable cohort studies by the combination of appropriate pulse sequences and cryogenically cooled resonators (CCR). The objective of this study was to apply this DTI approach at the group level to β-amyloid precursor protein (APP) transgenic mice.<h4>Methods</h4>Twelve mice (5 wild type, 7 APP transgenic tg2576) underwent DTI examination at 156(2) × 250 µm(3) spatial resolution with a CCR at ultrahigh field (11.7 T). Diffusion images were acquired along 30 gradient directions plus 5 references without diffusion encoding with a total acquisition time of 35 minutes. Fractional anisotropy (FA) maps were statistically compared by whole brain-based spatial statistics (WBSS) at the group level vs. wild type controls.<h4>Results</h4>FA-map comparison showed characteristic regional patterns of differences between the groups with localizations associated with Alzheimer's disease in humans, such as the hippocampus, the entorhinal cortex, and the caudoputamen.<h4>Conclusion</h4>In this proof-of-principle study, regions associated with amyloid-β deposition could be identified by WBSS of FA maps in APP transgenic mice vs. wild type mice. Thus, DTI in the mouse brain acquired at 11.7 T by use of a CCR was demonstrated to be feasible for cohort studies.
format	article
author	Hans-Peter Müller Jan Kassubek Ina Vernikouskaya Albert C Ludolph Detlef Stiller Volker Rasche
author_facet	Hans-Peter Müller Jan Kassubek Ina Vernikouskaya Albert C Ludolph Detlef Stiller Volker Rasche
author_sort	Hans-Peter Müller
title	Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
title_short	Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
title_full	Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
title_fullStr	Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
title_full_unstemmed	Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
title_sort	diffusion tensor magnetic resonance imaging of the brain in app transgenic mice: a cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3c58d5202da54fa4bffebb92a0ee4363
work_keys_str_mv	AT hanspetermuller diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy AT jankassubek diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy AT inavernikouskaya diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy AT albertcludolph diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy AT detlefstiller diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy AT volkerrasche diffusiontensormagneticresonanceimagingofthebraininapptransgenicmiceacohortstudy
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Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.

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