Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity

Abstract FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as...

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Autores principales:	Sagar Rayamajhi, Sarah Wilson, Santosh Aryal, Robert DeLong
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Iron phosphate nanoparticles Doxorubicin Drug delivery Drug loading RNA stabilization Biocompatible nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/3c5a0c2c8984423c997fbf810b978793
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spelling	oai:doaj.org-article:3c5a0c2c8984423c997fbf810b9787932021-11-28T12:37:27ZBiocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity10.1186/s11671-021-03626-81556-276Xhttps://doaj.org/article/3c5a0c2c8984423c997fbf810b9787932021-11-01T00:00:00Zhttps://doi.org/10.1186/s11671-021-03626-8https://doaj.org/toc/1556-276XAbstract FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO4 nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe3+ doxorubicin complex resulting in the formation of FePO4-DOX nanoparticles. FePO4-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe3+ complexation with DOX in FePO4-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO4 NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery.Sagar RayamajhiSarah WilsonSantosh AryalRobert DeLongSpringerOpenarticleIron phosphate nanoparticlesDoxorubicinDrug deliveryDrug loadingRNA stabilizationBiocompatible nanoparticlesMaterials of engineering and construction. Mechanics of materialsTA401-492ENNanoscale Research Letters, Vol 16, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Iron phosphate nanoparticles Doxorubicin Drug delivery Drug loading RNA stabilization Biocompatible nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Iron phosphate nanoparticles Doxorubicin Drug delivery Drug loading RNA stabilization Biocompatible nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492 Sagar Rayamajhi Sarah Wilson Santosh Aryal Robert DeLong Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
description	Abstract FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO4 nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe3+ doxorubicin complex resulting in the formation of FePO4-DOX nanoparticles. FePO4-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe3+ complexation with DOX in FePO4-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO4 NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery.
format	article
author	Sagar Rayamajhi Sarah Wilson Santosh Aryal Robert DeLong
author_facet	Sagar Rayamajhi Sarah Wilson Santosh Aryal Robert DeLong
author_sort	Sagar Rayamajhi
title	Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
title_short	Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
title_full	Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
title_fullStr	Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
title_full_unstemmed	Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
title_sort	biocompatible fepo4 nanoparticles: drug delivery, rna stabilization, and functional activity
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/3c5a0c2c8984423c997fbf810b978793
work_keys_str_mv	AT sagarrayamajhi biocompatiblefepo4nanoparticlesdrugdeliveryrnastabilizationandfunctionalactivity AT sarahwilson biocompatiblefepo4nanoparticlesdrugdeliveryrnastabilizationandfunctionalactivity AT santosharyal biocompatiblefepo4nanoparticlesdrugdeliveryrnastabilizationandfunctionalactivity AT robertdelong biocompatiblefepo4nanoparticlesdrugdeliveryrnastabilizationandfunctionalactivity
_version_	1718407886533558272

Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity

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