Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

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Bibliographic Details
Main Authors:	Jeffrey A. Schneider, Timothy W. Craven, Amanda C. Kasper, Chi Yun, Michael Haugbro, Erica M. Briggs, Vladimir Svetlov, Evgeny Nudler, Holger Knaut, Richard Bonneau, Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b
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spelling	oai:doaj.org-article:3c5aea308e6d452390e2d44fcb37b64b2021-12-02T14:39:07ZDesign of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer10.1038/s41467-018-06845-32041-1723https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06845-3https://doaj.org/toc/2041-1723Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.Jeffrey A. SchneiderTimothy W. CravenAmanda C. KasperChi YunMichael HaugbroErica M. BriggsVladimir SvetlovEvgeny NudlerHolger KnautRichard BonneauMichael J. GarabedianKent KirshenbaumSusan K. LoganNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
description	Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.
format	article
author	Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan
author_facet	Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan
author_sort	Jeffrey A. Schneider
title	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_short	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_full	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_fullStr	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_full_unstemmed	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_sort	design of peptoid-peptide macrocycles to inhibit the β-catenin tcf interaction in prostate cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b
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Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

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