Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeffrey A. Schneider, Timothy W. Craven, Amanda C. Kasper, Chi Yun, Michael Haugbro, Erica M. Briggs, Vladimir Svetlov, Evgeny Nudler, Holger Knaut, Richard Bonneau, Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c5aea308e6d452390e2d44fcb37b64b
record_format	dspace
spelling	oai:doaj.org-article:3c5aea308e6d452390e2d44fcb37b64b2021-12-02T14:39:07ZDesign of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer10.1038/s41467-018-06845-32041-1723https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06845-3https://doaj.org/toc/2041-1723Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.Jeffrey A. SchneiderTimothy W. CravenAmanda C. KasperChi YunMichael HaugbroErica M. BriggsVladimir SvetlovEvgeny NudlerHolger KnautRichard BonneauMichael J. GarabedianKent KirshenbaumSusan K. LoganNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
description	Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.
format	article
author	Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan
author_facet	Jeffrey A. Schneider Timothy W. Craven Amanda C. Kasper Chi Yun Michael Haugbro Erica M. Briggs Vladimir Svetlov Evgeny Nudler Holger Knaut Richard Bonneau Michael J. Garabedian Kent Kirshenbaum Susan K. Logan
author_sort	Jeffrey A. Schneider
title	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_short	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_full	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_fullStr	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_full_unstemmed	Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
title_sort	design of peptoid-peptide macrocycles to inhibit the β-catenin tcf interaction in prostate cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b
work_keys_str_mv	AT jeffreyaschneider designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT timothywcraven designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT amandackasper designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT chiyun designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT michaelhaugbro designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT ericambriggs designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT vladimirsvetlov designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT evgenynudler designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT holgerknaut designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT richardbonneau designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT michaeljgarabedian designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT kentkirshenbaum designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer AT susanklogan designofpeptoidpeptidemacrocyclestoinhibitthebcatenintcfinteractioninprostatecancer
_version_	1718390708931395584

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Ejemplares similares