Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases

The gold standard method for chronic liver diseases diagnosis and staging remains liver biopsy, despite the spread of less invasive surrogate modalities based on imaging and blood biomarkers. Still, more than 50% of chronic liver disease cases are detected at later stages when patients exhibit episo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antonio Murgia, Yusuf Ahmed, Kelly Sweeney, Louise Nicholson-Scott, Kayleigh Arthur, Max Allsworth, Billy Boyle, Olga Gandelman, Agnieszka Smolinska, Giuseppe Ferrandino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breath biopsy volatile organic compounds (VOC) chronic liver diseases Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3c5b07728d0948c59f7e7d4218e22143
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c5b07728d0948c59f7e7d4218e22143
record_format	dspace
spelling	oai:doaj.org-article:3c5b07728d0948c59f7e7d4218e221432021-11-25T16:49:04ZBreath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases10.3390/biomedicines91115632227-9059https://doaj.org/article/3c5b07728d0948c59f7e7d4218e221432021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1563https://doaj.org/toc/2227-9059The gold standard method for chronic liver diseases diagnosis and staging remains liver biopsy, despite the spread of less invasive surrogate modalities based on imaging and blood biomarkers. Still, more than 50% of chronic liver disease cases are detected at later stages when patients exhibit episodes of liver decompensation. Breath analysis represents an attractive means for the development of non-invasive tests for several pathologies, including chronic liver diseases. In this perspective review, we summarize the main findings of studies that compared the breath of patients with chronic liver diseases against that of control subjects and found candidate biomarkers for a potential breath test. Interestingly, identified compounds with best classification performance are of exogenous origin and used as flavoring agents in food. Therefore, random dietary exposure of the general population to these compounds prevents the establishment of threshold levels for the identification of disease subjects. To overcome this limitation, we propose the exogenous volatile organic compounds (EVOCs) probe approach, where one or multiple of these flavoring agent(s) are administered at a standard dose and liver dysfunction associated with chronic liver diseases is evaluated as a washout of ingested compound(s). We report preliminary results in healthy subjects in support of the potential of the EVOC Probe approach.Antonio MurgiaYusuf AhmedKelly SweeneyLouise Nicholson-ScottKayleigh ArthurMax AllsworthBilly BoyleOlga GandelmanAgnieszka SmolinskaGiuseppe FerrandinoMDPI AGarticlebreath biopsyvolatile organic compounds (VOC)chronic liver diseasesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1563, p 1563 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breath biopsy volatile organic compounds (VOC) chronic liver diseases Biology (General) QH301-705.5
spellingShingle	breath biopsy volatile organic compounds (VOC) chronic liver diseases Biology (General) QH301-705.5 Antonio Murgia Yusuf Ahmed Kelly Sweeney Louise Nicholson-Scott Kayleigh Arthur Max Allsworth Billy Boyle Olga Gandelman Agnieszka Smolinska Giuseppe Ferrandino Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
description	The gold standard method for chronic liver diseases diagnosis and staging remains liver biopsy, despite the spread of less invasive surrogate modalities based on imaging and blood biomarkers. Still, more than 50% of chronic liver disease cases are detected at later stages when patients exhibit episodes of liver decompensation. Breath analysis represents an attractive means for the development of non-invasive tests for several pathologies, including chronic liver diseases. In this perspective review, we summarize the main findings of studies that compared the breath of patients with chronic liver diseases against that of control subjects and found candidate biomarkers for a potential breath test. Interestingly, identified compounds with best classification performance are of exogenous origin and used as flavoring agents in food. Therefore, random dietary exposure of the general population to these compounds prevents the establishment of threshold levels for the identification of disease subjects. To overcome this limitation, we propose the exogenous volatile organic compounds (EVOCs) probe approach, where one or multiple of these flavoring agent(s) are administered at a standard dose and liver dysfunction associated with chronic liver diseases is evaluated as a washout of ingested compound(s). We report preliminary results in healthy subjects in support of the potential of the EVOC Probe approach.
format	article
author	Antonio Murgia Yusuf Ahmed Kelly Sweeney Louise Nicholson-Scott Kayleigh Arthur Max Allsworth Billy Boyle Olga Gandelman Agnieszka Smolinska Giuseppe Ferrandino
author_facet	Antonio Murgia Yusuf Ahmed Kelly Sweeney Louise Nicholson-Scott Kayleigh Arthur Max Allsworth Billy Boyle Olga Gandelman Agnieszka Smolinska Giuseppe Ferrandino
author_sort	Antonio Murgia
title	Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
title_short	Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
title_full	Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
title_fullStr	Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
title_full_unstemmed	Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases
title_sort	breath-taking perspectives and preliminary data toward early detection of chronic liver diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3c5b07728d0948c59f7e7d4218e22143
work_keys_str_mv	AT antoniomurgia breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT yusufahmed breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT kellysweeney breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT louisenicholsonscott breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT kayleigharthur breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT maxallsworth breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT billyboyle breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT olgagandelman breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT agnieszkasmolinska breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases AT giuseppeferrandino breathtakingperspectivesandpreliminarydatatowardearlydetectionofchronicliverdiseases
_version_	1718412948250034176

Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases

Ejemplares similares