Transmembrane but not soluble helices fold inside the ribosome tunnel

Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.

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Autores principales:	Manuel Bañó-Polo, Carlos Baeza-Delgado, Silvia Tamborero, Anthony Hazel, Brayan Grau, IngMarie Nilsson, Paul Whitley, James C. Gumbart, Gunnar von Heijne, Ismael Mingarro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c5b89887b174ab79e5d3eb70d8006cc
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spelling	oai:doaj.org-article:3c5b89887b174ab79e5d3eb70d8006cc2021-12-02T14:40:55ZTransmembrane but not soluble helices fold inside the ribosome tunnel10.1038/s41467-018-07554-72041-1723https://doaj.org/article/3c5b89887b174ab79e5d3eb70d8006cc2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07554-7https://doaj.org/toc/2041-1723Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.Manuel Bañó-PoloCarlos Baeza-DelgadoSilvia TamboreroAnthony HazelBrayan GrauIngMarie NilssonPaul WhitleyJames C. GumbartGunnar von HeijneIsmael MingarroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manuel Bañó-Polo Carlos Baeza-Delgado Silvia Tamborero Anthony Hazel Brayan Grau IngMarie Nilsson Paul Whitley James C. Gumbart Gunnar von Heijne Ismael Mingarro Transmembrane but not soluble helices fold inside the ribosome tunnel
description	Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.
format	article
author	Manuel Bañó-Polo Carlos Baeza-Delgado Silvia Tamborero Anthony Hazel Brayan Grau IngMarie Nilsson Paul Whitley James C. Gumbart Gunnar von Heijne Ismael Mingarro
author_facet	Manuel Bañó-Polo Carlos Baeza-Delgado Silvia Tamborero Anthony Hazel Brayan Grau IngMarie Nilsson Paul Whitley James C. Gumbart Gunnar von Heijne Ismael Mingarro
author_sort	Manuel Bañó-Polo
title	Transmembrane but not soluble helices fold inside the ribosome tunnel
title_short	Transmembrane but not soluble helices fold inside the ribosome tunnel
title_full	Transmembrane but not soluble helices fold inside the ribosome tunnel
title_fullStr	Transmembrane but not soluble helices fold inside the ribosome tunnel
title_full_unstemmed	Transmembrane but not soluble helices fold inside the ribosome tunnel
title_sort	transmembrane but not soluble helices fold inside the ribosome tunnel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c5b89887b174ab79e5d3eb70d8006cc
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Transmembrane but not soluble helices fold inside the ribosome tunnel

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