Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.

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Autores principales:	Meilin Chan, Licun Wu, Zhihong Yun, Trevor D. McKee, Michael Cabanero, Yidan Zhao, Mikihiro Kohno, Junichi Murakami, Marc de Perrot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3c5ca878a66742d7a38438d115052146
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spelling	oai:doaj.org-article:3c5ca878a66742d7a38438d1150521462021-12-02T16:06:36ZBlocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma10.1038/s42003-021-02430-52399-3642https://doaj.org/article/3c5ca878a66742d7a38438d1150521462021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02430-5https://doaj.org/toc/2399-3642Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.Meilin ChanLicun WuZhihong YunTrevor D. McKeeMichael CabaneroYidan ZhaoMikihiro KohnoJunichi MurakamiMarc de PerrotNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Meilin Chan Licun Wu Zhihong Yun Trevor D. McKee Michael Cabanero Yidan Zhao Mikihiro Kohno Junichi Murakami Marc de Perrot Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
description	Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.
format	article
author	Meilin Chan Licun Wu Zhihong Yun Trevor D. McKee Michael Cabanero Yidan Zhao Mikihiro Kohno Junichi Murakami Marc de Perrot
author_facet	Meilin Chan Licun Wu Zhihong Yun Trevor D. McKee Michael Cabanero Yidan Zhao Mikihiro Kohno Junichi Murakami Marc de Perrot
author_sort	Meilin Chan
title	Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
title_short	Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
title_full	Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
title_fullStr	Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
title_full_unstemmed	Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
title_sort	blocking the gitr-gitrl pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c5ca878a66742d7a38438d115052146
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Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

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