Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.

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Autores principales: Meilin Chan, Licun Wu, Zhihong Yun, Trevor D. McKee, Michael Cabanero, Yidan Zhao, Mikihiro Kohno, Junichi Murakami, Marc de Perrot
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3c5ca878a66742d7a38438d115052146
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