Study on the anti-gout effects of four herbs extracts
Objective: To explore the anti-gout effects of four traditional Chinese medicine extracts of Eucommia,Sargentodoxa cuneata,Caulis spatholobi and Phellinus igniarius. Methods: Monosodium Urate (MSU) was used to establish a mouse gouty arritis model. With coloricine as the positive control group, t...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Editorial Board of Journal of Hainan Medical University
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3c643a83ec6343c9bc01f0c54aa5cbd7 |
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| Sumario: | Objective: To explore the anti-gout effects of four traditional Chinese medicine extracts
of Eucommia,Sargentodoxa cuneata,Caulis spatholobi and Phellinus igniarius. Methods:
Monosodium Urate (MSU) was used to establish a mouse gouty arritis model. With coloricine
as the positive control group, the effects of four traditional Chinese medicine extracts of
Ecuador, Sargentodoxa, Caulis spatholobi and Phellinus igniarius on rice were studied; The
hot plate method was used to observe the analytical effects of the four groups of traditional
Chinese medicine extracts; the enzyme-linked immunoassay (ELISA) was used to detect
residual interference-1 beta (IL-1 beta); the four traditional Chinese medicine extracts were
simultaneously determined on the white blood cells, and monocytes in the blood of mice as
well as the influence of neutrophils and histopathological changes of toes. Results: Compared
with the normal group, the joint diameter ratio, blood leukocytes, monocytes, neutrophils, IL-
1βat different time points in the model group were significantly increased (P <0.01), and the
pain percentage was significantly reduced (P <0.05). Compared with the model group, the
joint diameter ratio of the colchicine group, the Eucommia group, the Sargentodoxa group, the
Caulis spatholobi group and the Phellinus sibiricum group was significantly reduced (P <0.05),
and the pain percentage was significantly increased (P (0.05). The four groups of traditional
Chinese medicine extracts significantly decreased the white blood cells, monocytes, and
neutrophils in the blood of mice (P <0.05), and the IL-1βexpression levels of the Eucommia
ulmoides group,) the Sargentodoxa group and the Phellinus igniarius group significantly
decreased (P <0.05). Eucommia ulmoides and Caulis spatholobi are more effective in reducing
pathological damage of toes in mice. Conclusion: The water extract of Caulis spatholobi has
obvious anti-gout effect,and the most significant effect on analgesia and swelling. Eucommia
ulmoides and Sargentodoxa cuneata have more obvious anti-inflammatory effects and have
certain analgesic and swelling effects. Phellinus Phellinus igniarius has obvious inhibitory
effect on IL-1β,but it does not show good anti-gout potential. |
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