Study on the anti-gout effects of four herbs extracts

Objective: To explore the anti-gout effects of four traditional Chinese medicine extracts of Eucommia,Sargentodoxa cuneata,Caulis spatholobi and Phellinus igniarius. Methods: Monosodium Urate (MSU) was used to establish a mouse gouty arritis model. With coloricine as the positive control group, t...

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Autores principales:	Hao-Lin Wu, Qi-Bing Liu
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	gout herb extract anti-inflammatory analgesia interleukin-1β Medicine R
Acceso en línea:	https://doaj.org/article/3c643a83ec6343c9bc01f0c54aa5cbd7
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spelling	oai:doaj.org-article:3c643a83ec6343c9bc01f0c54aa5cbd72021-11-16T01:20:36ZStudy on the anti-gout effects of four herbs extracts1007-1237https://doaj.org/article/3c643a83ec6343c9bc01f0c54aa5cbd72021-09-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202119/02.pdfhttps://doaj.org/toc/1007-1237Objective: To explore the anti-gout effects of four traditional Chinese medicine extracts of Eucommia,Sargentodoxa cuneata,Caulis spatholobi and Phellinus igniarius. Methods: Monosodium Urate (MSU) was used to establish a mouse gouty arritis model. With coloricine as the positive control group, the effects of four traditional Chinese medicine extracts of Ecuador, Sargentodoxa, Caulis spatholobi and Phellinus igniarius on rice were studied; The hot plate method was used to observe the analytical effects of the four groups of traditional Chinese medicine extracts; the enzyme-linked immunoassay (ELISA) was used to detect residual interference-1 beta (IL-1 beta); the four traditional Chinese medicine extracts were simultaneously determined on the white blood cells, and monocytes in the blood of mice as well as the influence of neutrophils and histopathological changes of toes. Results: Compared with the normal group, the joint diameter ratio, blood leukocytes, monocytes, neutrophils, IL- 1βat different time points in the model group were significantly increased (P <0.01), and the pain percentage was significantly reduced (P <0.05). Compared with the model group, the joint diameter ratio of the colchicine group, the Eucommia group, the Sargentodoxa group, the Caulis spatholobi group and the Phellinus sibiricum group was significantly reduced (P <0.05), and the pain percentage was significantly increased (P (0.05). The four groups of traditional Chinese medicine extracts significantly decreased the white blood cells, monocytes, and neutrophils in the blood of mice (P <0.05), and the IL-1βexpression levels of the Eucommia ulmoides group,) the Sargentodoxa group and the Phellinus igniarius group significantly decreased (P <0.05). Eucommia ulmoides and Caulis spatholobi are more effective in reducing pathological damage of toes in mice. Conclusion: The water extract of Caulis spatholobi has obvious anti-gout effect,and the most significant effect on analgesia and swelling. Eucommia ulmoides and Sargentodoxa cuneata have more obvious anti-inflammatory effects and have certain analgesic and swelling effects. Phellinus Phellinus igniarius has obvious inhibitory effect on IL-1β,but it does not show good anti-gout potential.Hao-Lin WuQi-Bing LiuEditorial Board of Journal of Hainan Medical Universityarticlegoutherb extractanti-inflammatoryanalgesiainterleukin-1βMedicineRENJournal of Hainan Medical University, Vol 27, Iss 19, Pp 2-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gout herb extract anti-inflammatory analgesia interleukin-1β Medicine R
spellingShingle	gout herb extract anti-inflammatory analgesia interleukin-1β Medicine R Hao-Lin Wu Qi-Bing Liu Study on the anti-gout effects of four herbs extracts
description	Objective: To explore the anti-gout effects of four traditional Chinese medicine extracts of Eucommia,Sargentodoxa cuneata,Caulis spatholobi and Phellinus igniarius. Methods: Monosodium Urate (MSU) was used to establish a mouse gouty arritis model. With coloricine as the positive control group, the effects of four traditional Chinese medicine extracts of Ecuador, Sargentodoxa, Caulis spatholobi and Phellinus igniarius on rice were studied; The hot plate method was used to observe the analytical effects of the four groups of traditional Chinese medicine extracts; the enzyme-linked immunoassay (ELISA) was used to detect residual interference-1 beta (IL-1 beta); the four traditional Chinese medicine extracts were simultaneously determined on the white blood cells, and monocytes in the blood of mice as well as the influence of neutrophils and histopathological changes of toes. Results: Compared with the normal group, the joint diameter ratio, blood leukocytes, monocytes, neutrophils, IL- 1βat different time points in the model group were significantly increased (P <0.01), and the pain percentage was significantly reduced (P <0.05). Compared with the model group, the joint diameter ratio of the colchicine group, the Eucommia group, the Sargentodoxa group, the Caulis spatholobi group and the Phellinus sibiricum group was significantly reduced (P <0.05), and the pain percentage was significantly increased (P (0.05). The four groups of traditional Chinese medicine extracts significantly decreased the white blood cells, monocytes, and neutrophils in the blood of mice (P <0.05), and the IL-1βexpression levels of the Eucommia ulmoides group,) the Sargentodoxa group and the Phellinus igniarius group significantly decreased (P <0.05). Eucommia ulmoides and Caulis spatholobi are more effective in reducing pathological damage of toes in mice. Conclusion: The water extract of Caulis spatholobi has obvious anti-gout effect,and the most significant effect on analgesia and swelling. Eucommia ulmoides and Sargentodoxa cuneata have more obvious anti-inflammatory effects and have certain analgesic and swelling effects. Phellinus Phellinus igniarius has obvious inhibitory effect on IL-1β,but it does not show good anti-gout potential.
format	article
author	Hao-Lin Wu Qi-Bing Liu
author_facet	Hao-Lin Wu Qi-Bing Liu
author_sort	Hao-Lin Wu
title	Study on the anti-gout effects of four herbs extracts
title_short	Study on the anti-gout effects of four herbs extracts
title_full	Study on the anti-gout effects of four herbs extracts
title_fullStr	Study on the anti-gout effects of four herbs extracts
title_full_unstemmed	Study on the anti-gout effects of four herbs extracts
title_sort	study on the anti-gout effects of four herbs extracts
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/3c643a83ec6343c9bc01f0c54aa5cbd7
work_keys_str_mv	AT haolinwu studyontheantigouteffectsoffourherbsextracts AT qibingliu studyontheantigouteffectsoffourherbsextracts
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Study on the anti-gout effects of four herbs extracts

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