Tunable genetic devices through simultaneous control of transcription and translation

Synthetic genetic circuits are sensitive to their environment and host cell, requiring many rounds of physical reassembly to achieve a desired function. Here the authors use a multi-level regulatory motif to dynamically tune the function of genetic parts as a step towards robust adaptive circuits.

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Autores principales:	Vittorio Bartoli, Grace A. Meaker, Mario di Bernardo, Thomas E. Gorochowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c64e96ed5e9493bac7f1b5bff3219ee
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spelling	oai:doaj.org-article:3c64e96ed5e9493bac7f1b5bff3219ee2021-12-02T17:32:28ZTunable genetic devices through simultaneous control of transcription and translation10.1038/s41467-020-15653-72041-1723https://doaj.org/article/3c64e96ed5e9493bac7f1b5bff3219ee2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15653-7https://doaj.org/toc/2041-1723Synthetic genetic circuits are sensitive to their environment and host cell, requiring many rounds of physical reassembly to achieve a desired function. Here the authors use a multi-level regulatory motif to dynamically tune the function of genetic parts as a step towards robust adaptive circuits.Vittorio BartoliGrace A. MeakerMario di BernardoThomas E. GorochowskiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vittorio Bartoli Grace A. Meaker Mario di Bernardo Thomas E. Gorochowski Tunable genetic devices through simultaneous control of transcription and translation
description	Synthetic genetic circuits are sensitive to their environment and host cell, requiring many rounds of physical reassembly to achieve a desired function. Here the authors use a multi-level regulatory motif to dynamically tune the function of genetic parts as a step towards robust adaptive circuits.
format	article
author	Vittorio Bartoli Grace A. Meaker Mario di Bernardo Thomas E. Gorochowski
author_facet	Vittorio Bartoli Grace A. Meaker Mario di Bernardo Thomas E. Gorochowski
author_sort	Vittorio Bartoli
title	Tunable genetic devices through simultaneous control of transcription and translation
title_short	Tunable genetic devices through simultaneous control of transcription and translation
title_full	Tunable genetic devices through simultaneous control of transcription and translation
title_fullStr	Tunable genetic devices through simultaneous control of transcription and translation
title_full_unstemmed	Tunable genetic devices through simultaneous control of transcription and translation
title_sort	tunable genetic devices through simultaneous control of transcription and translation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c64e96ed5e9493bac7f1b5bff3219ee
work_keys_str_mv	AT vittoriobartoli tunablegeneticdevicesthroughsimultaneouscontroloftranscriptionandtranslation AT graceameaker tunablegeneticdevicesthroughsimultaneouscontroloftranscriptionandtranslation AT mariodibernardo tunablegeneticdevicesthroughsimultaneouscontroloftranscriptionandtranslation AT thomasegorochowski tunablegeneticdevicesthroughsimultaneouscontroloftranscriptionandtranslation
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Tunable genetic devices through simultaneous control of transcription and translation

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