Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma

<i>Background and Objectives:</i> Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katharina Jäckle, Friederike Klockner, Daniel Bernd Hoffmann, Paul Jonathan Roch, Maximilian Reinhold, Wolfgang Lehmann, Lukas Weiser
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoporosis chronic hyponatremia QCT BMD spine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3c65a76ae49a40b08b80d4a58e04aeb1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c65a76ae49a40b08b80d4a58e04aeb1
record_format	dspace
spelling	oai:doaj.org-article:3c65a76ae49a40b08b80d4a58e04aeb12021-11-25T18:18:44ZInfluence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma10.3390/medicina571112241648-91441010-660Xhttps://doaj.org/article/3c65a76ae49a40b08b80d4a58e04aeb12021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1224https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives:</i> Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. <i>Materials and Methods:</i> 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. <i>Results:</i> Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (<i>p</i> = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; <i>p</i>* < 0.001). <i>Conclusions:</i> The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients.Katharina JäckleFriederike KlocknerDaniel Bernd HoffmannPaul Jonathan RochMaximilian ReinholdWolfgang LehmannLukas WeiserMDPI AGarticleosteoporosischronic hyponatremiaQCTBMDspineMedicine (General)R5-920ENMedicina, Vol 57, Iss 1224, p 1224 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis chronic hyponatremia QCT BMD spine Medicine (General) R5-920
spellingShingle	osteoporosis chronic hyponatremia QCT BMD spine Medicine (General) R5-920 Katharina Jäckle Friederike Klockner Daniel Bernd Hoffmann Paul Jonathan Roch Maximilian Reinhold Wolfgang Lehmann Lukas Weiser Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
description	<i>Background and Objectives:</i> Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. <i>Materials and Methods:</i> 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. <i>Results:</i> Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (<i>p</i> = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; <i>p</i>* < 0.001). <i>Conclusions:</i> The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients.
format	article
author	Katharina Jäckle Friederike Klockner Daniel Bernd Hoffmann Paul Jonathan Roch Maximilian Reinhold Wolfgang Lehmann Lukas Weiser
author_facet	Katharina Jäckle Friederike Klockner Daniel Bernd Hoffmann Paul Jonathan Roch Maximilian Reinhold Wolfgang Lehmann Lukas Weiser
author_sort	Katharina Jäckle
title	Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
title_short	Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
title_full	Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
title_fullStr	Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
title_full_unstemmed	Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
title_sort	influence of hyponatremia on spinal bone quality and fractures due to low-energy trauma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3c65a76ae49a40b08b80d4a58e04aeb1
work_keys_str_mv	AT katharinajackle influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT friederikeklockner influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT danielberndhoffmann influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT pauljonathanroch influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT maximilianreinhold influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT wolfganglehmann influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma AT lukasweiser influenceofhyponatremiaonspinalbonequalityandfracturesduetolowenergytrauma
_version_	1718411313334452224

Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma

Ejemplares similares