ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of...

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Autores principales:	Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c65e1c5ccf540638c6d891c8d6bd90e
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spelling	oai:doaj.org-article:3c65e1c5ccf540638c6d891c8d6bd90e2021-12-02T14:39:43ZACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity10.1038/s41467-018-03080-82041-1723https://doaj.org/article/3c65e1c5ccf540638c6d891c8d6bd90e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03080-8https://doaj.org/toc/2041-1723The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.Matteo MassaraOrnella BonavitaBenedetta SavinoNicoletta CaronniValeria Mollica PoetaMarina SironiElisa SettenCamilla RecordatiLaura CrisafulliFrancesca FicaraAlberto MantovaniMassimo LocatiRaffaella BonecchiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Massara Ornella Bonavita Benedetta Savino Nicoletta Caronni Valeria Mollica Poeta Marina Sironi Elisa Setten Camilla Recordati Laura Crisafulli Francesca Ficara Alberto Mantovani Massimo Locati Raffaella Bonecchi ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
description	The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.
format	article
author	Matteo Massara Ornella Bonavita Benedetta Savino Nicoletta Caronni Valeria Mollica Poeta Marina Sironi Elisa Setten Camilla Recordati Laura Crisafulli Francesca Ficara Alberto Mantovani Massimo Locati Raffaella Bonecchi
author_facet	Matteo Massara Ornella Bonavita Benedetta Savino Nicoletta Caronni Valeria Mollica Poeta Marina Sironi Elisa Setten Camilla Recordati Laura Crisafulli Francesca Ficara Alberto Mantovani Massimo Locati Raffaella Bonecchi
author_sort	Matteo Massara
title	ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
title_short	ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
title_full	ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
title_fullStr	ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
title_full_unstemmed	ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
title_sort	ackr2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c65e1c5ccf540638c6d891c8d6bd90e
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ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

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