ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of...

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Bibliographic Details
Main Authors: Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/3c65e1c5ccf540638c6d891c8d6bd90e
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