Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development

Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development

Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is associated with reduced diabetes development in people...

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Autores principales: Jayakrishna Ambati, Joseph Magagnoli, Hannah Leung, Shao-bin Wang, Chris A. Andrews, Dongxu Fu, Akshat Pandey, Srabani Sahu, Siddharth Narendran, Shuichiro Hirahara, Shinichi Fukuda, Jian Sun, Lekha Pandya, Meenakshi Ambati, Felipe Pereira, Akhil Varshney, Tammy Cummings, James W. Hardin, Babatunde Edun, Charles L. Bennett, Kameshwari Ambati, Benjamin J. Fowler, Nagaraj Kerur, Christian Röver, Norbert Leitinger, Brian C. Werner, Joshua D. Stein, S. Scott Sutton, Bradley D. Gelfand
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3c663125a9b94db7a11c2309f51581c5
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spelling oai:doaj.org-article:3c663125a9b94db7a11c2309f51581c52021-12-02T15:14:37ZRepurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development10.1038/s41467-020-18528-z2041-1723https://doaj.org/article/3c663125a9b94db7a11c2309f51581c52020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18528-zhttps://doaj.org/toc/2041-1723Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is associated with reduced diabetes development in people and improves insulin sensitivity in experimental settings.Jayakrishna AmbatiJoseph MagagnoliHannah LeungShao-bin WangChris A. AndrewsDongxu FuAkshat PandeySrabani SahuSiddharth NarendranShuichiro HiraharaShinichi FukudaJian SunLekha PandyaMeenakshi AmbatiFelipe PereiraAkhil VarshneyTammy CummingsJames W. HardinBabatunde EdunCharles L. BennettKameshwari AmbatiBenjamin J. FowlerNagaraj KerurChristian RöverNorbert LeitingerBrian C. WernerJoshua D. SteinS. Scott SuttonBradley D. GelfandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jayakrishna Ambati
Joseph Magagnoli
Hannah Leung
Shao-bin Wang
Chris A. Andrews
Dongxu Fu
Akshat Pandey
Srabani Sahu
Siddharth Narendran
Shuichiro Hirahara
Shinichi Fukuda
Jian Sun
Lekha Pandya
Meenakshi Ambati
Felipe Pereira
Akhil Varshney
Tammy Cummings
James W. Hardin
Babatunde Edun
Charles L. Bennett
Kameshwari Ambati
Benjamin J. Fowler
Nagaraj Kerur
Christian Röver
Norbert Leitinger
Brian C. Werner
Joshua D. Stein
S. Scott Sutton
Bradley D. Gelfand
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
description Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is associated with reduced diabetes development in people and improves insulin sensitivity in experimental settings.
format article
author Jayakrishna Ambati
Joseph Magagnoli
Hannah Leung
Shao-bin Wang
Chris A. Andrews
Dongxu Fu
Akshat Pandey
Srabani Sahu
Siddharth Narendran
Shuichiro Hirahara
Shinichi Fukuda
Jian Sun
Lekha Pandya
Meenakshi Ambati
Felipe Pereira
Akhil Varshney
Tammy Cummings
James W. Hardin
Babatunde Edun
Charles L. Bennett
Kameshwari Ambati
Benjamin J. Fowler
Nagaraj Kerur
Christian Röver
Norbert Leitinger
Brian C. Werner
Joshua D. Stein
S. Scott Sutton
Bradley D. Gelfand
author_facet Jayakrishna Ambati
Joseph Magagnoli
Hannah Leung
Shao-bin Wang
Chris A. Andrews
Dongxu Fu
Akshat Pandey
Srabani Sahu
Siddharth Narendran
Shuichiro Hirahara
Shinichi Fukuda
Jian Sun
Lekha Pandya
Meenakshi Ambati
Felipe Pereira
Akhil Varshney
Tammy Cummings
James W. Hardin
Babatunde Edun
Charles L. Bennett
Kameshwari Ambati
Benjamin J. Fowler
Nagaraj Kerur
Christian Röver
Norbert Leitinger
Brian C. Werner
Joshua D. Stein
S. Scott Sutton
Bradley D. Gelfand
author_sort Jayakrishna Ambati
title Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
title_short Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
title_full Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
title_fullStr Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
title_full_unstemmed Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
title_sort repurposing anti-inflammasome nrtis for improving insulin sensitivity and reducing type 2 diabetes development
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3c663125a9b94db7a11c2309f51581c5
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