Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study

Abstract Background Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19, and hence is a target of intervention, or whether it is a symptom, is unclear because conventional observational studies are open to confound...

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Autores principales:	Jie V. Zhao, C. Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/3c669e3ede624482ad9dd9feade77c76
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spelling	oai:doaj.org-article:3c669e3ede624482ad9dd9feade77c762021-11-14T12:43:55ZUsing genetics to understand the role of kidney function in COVID-19: a mendelian randomization study10.1186/s12882-021-02586-61471-2369https://doaj.org/article/3c669e3ede624482ad9dd9feade77c762021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02586-6https://doaj.org/toc/1471-2369Abstract Background Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19, and hence is a target of intervention, or whether it is a symptom, is unclear because conventional observational studies are open to confounding. To obtain unconfounded estimates, we used Mendelian randomization to examine the role of kidney function in severe COVID-19. Methods We used genome-wide significant, uncorrelated genetic variants to predict kidney function, in terms of estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR), and then assessed whether people with genetically instrumented higher eGFR or lower UACR, an indication of better kidney function, had a lower risk of severe COVID-19 (8779 cases, 1,001,875 controls), using the largest available cohorts with extensive genotyping. For comprehensiveness, we also examined their role in COVID-19 hospitalization (24,274 cases, 2,061,529 controls) and all COVID-19 (1,12,612 cases, 2,474,079 controls). Results Genetically instrumented higher eGFR was associated with lower risk of severe COVID-19 (odds ratio (OR) 0.90, 95% confidence interval (CI) 0.83, 0.98) but not related to COVID-19 hospitalization or infection. Genetically instrumented UACR was not related to COVID-19. Conclusions Kidney function appears to be one of the key targets for severe COVID-19 treatment. Use of available medications to improve kidney function, such as antihypertensives, might be beneficial for COVID-19 treatment, with relevance to drug repositioning.Jie V. ZhaoC. Mary SchoolingBMCarticleDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Jie V. Zhao C. Mary Schooling Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
description	Abstract Background Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19, and hence is a target of intervention, or whether it is a symptom, is unclear because conventional observational studies are open to confounding. To obtain unconfounded estimates, we used Mendelian randomization to examine the role of kidney function in severe COVID-19. Methods We used genome-wide significant, uncorrelated genetic variants to predict kidney function, in terms of estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR), and then assessed whether people with genetically instrumented higher eGFR or lower UACR, an indication of better kidney function, had a lower risk of severe COVID-19 (8779 cases, 1,001,875 controls), using the largest available cohorts with extensive genotyping. For comprehensiveness, we also examined their role in COVID-19 hospitalization (24,274 cases, 2,061,529 controls) and all COVID-19 (1,12,612 cases, 2,474,079 controls). Results Genetically instrumented higher eGFR was associated with lower risk of severe COVID-19 (odds ratio (OR) 0.90, 95% confidence interval (CI) 0.83, 0.98) but not related to COVID-19 hospitalization or infection. Genetically instrumented UACR was not related to COVID-19. Conclusions Kidney function appears to be one of the key targets for severe COVID-19 treatment. Use of available medications to improve kidney function, such as antihypertensives, might be beneficial for COVID-19 treatment, with relevance to drug repositioning.
format	article
author	Jie V. Zhao C. Mary Schooling
author_facet	Jie V. Zhao C. Mary Schooling
author_sort	Jie V. Zhao
title	Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
title_short	Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
title_full	Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
title_fullStr	Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
title_full_unstemmed	Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
title_sort	using genetics to understand the role of kidney function in covid-19: a mendelian randomization study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3c669e3ede624482ad9dd9feade77c76
work_keys_str_mv	AT jievzhao usinggeneticstounderstandtheroleofkidneyfunctionincovid19amendelianrandomizationstudy AT cmaryschooling usinggeneticstounderstandtheroleofkidneyfunctionincovid19amendelianrandomizationstudy
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Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study

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