Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.

<h4>Background</h4>The subtype diversity of the hepatitis C virus (HCV) genotypes is unknown in Venezuela.<h4>Methodology/principal findings</h4>Partial sequencing of the NS5B region was performed in 310 isolates circulating in patients from 1995 to 2007. In the samples colle...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Z Sulbarán, Federico A Di Lello, Yoneira Sulbarán, Clarisa Cosson, Carmen L Loureiro, Héctor R Rangel, Jean F Cantaloube, Rodolfo H Campos, Gonzalo Moratorio, Juan Cristina, Flor H Pujol
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c6cb8b7c3da4db0930bdfd3cff9a92b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c6cb8b7c3da4db0930bdfd3cff9a92b
record_format	dspace
spelling	oai:doaj.org-article:3c6cb8b7c3da4db0930bdfd3cff9a92b2021-11-18T07:01:47ZGenetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.1932-620310.1371/journal.pone.0014315https://doaj.org/article/3c6cb8b7c3da4db0930bdfd3cff9a92b2010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179440/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The subtype diversity of the hepatitis C virus (HCV) genotypes is unknown in Venezuela.<h4>Methodology/principal findings</h4>Partial sequencing of the NS5B region was performed in 310 isolates circulating in patients from 1995 to 2007. In the samples collected between 2005 and 2007, HCV genotype 1 (G1) was the most common genotype (63%), composed as expected of mainly G1a and G1b. G2 was the second most common genotype (33%), being G2a almost absent and G2j the most frequent subtype. Sequence analysis of the core region confirmed the subtype assignment performed within the NS5b region in 63 isolates. The complete genome sequence of G2j was obtained. G2j has been described in France, Canada and Burkina Fasso, but it was not found in Martinique, where several subtypes of G2 circulate in the general population. Bayesian coalescence analysis indicated a most recent common ancestor (MRCA) of G2j around 1785, before the introduction of G1b (1869) and G1a (1922). While HCV G1a and G1b experienced a growth reduction since 1990, coincident with the time when blood testing was implemented in Venezuela, HCV G2j did not seem to reach growth equilibrium during this period.<h4>Conclusions/significance</h4>Assuming the introduction of G2j from Africa during the slave trade, the high frequency of G2j found in Venezuela could suggest: 1- the introduction of African ethnic groups different from the ones introduced to Martinique or 2- the occurrence of a founder effect. This study represents an in-depth analysis of the subtype diversity of HCV in Venezuela, which is still unexplored in the Americas and deserves further studies.Maria Z SulbaránFederico A Di LelloYoneira SulbaránClarisa CossonCarmen L LoureiroHéctor R RangelJean F CantaloubeRodolfo H CamposGonzalo MoratorioJuan CristinaFlor H PujolPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e14315 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Z Sulbarán Federico A Di Lello Yoneira Sulbarán Clarisa Cosson Carmen L Loureiro Héctor R Rangel Jean F Cantaloube Rodolfo H Campos Gonzalo Moratorio Juan Cristina Flor H Pujol Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
description	<h4>Background</h4>The subtype diversity of the hepatitis C virus (HCV) genotypes is unknown in Venezuela.<h4>Methodology/principal findings</h4>Partial sequencing of the NS5B region was performed in 310 isolates circulating in patients from 1995 to 2007. In the samples collected between 2005 and 2007, HCV genotype 1 (G1) was the most common genotype (63%), composed as expected of mainly G1a and G1b. G2 was the second most common genotype (33%), being G2a almost absent and G2j the most frequent subtype. Sequence analysis of the core region confirmed the subtype assignment performed within the NS5b region in 63 isolates. The complete genome sequence of G2j was obtained. G2j has been described in France, Canada and Burkina Fasso, but it was not found in Martinique, where several subtypes of G2 circulate in the general population. Bayesian coalescence analysis indicated a most recent common ancestor (MRCA) of G2j around 1785, before the introduction of G1b (1869) and G1a (1922). While HCV G1a and G1b experienced a growth reduction since 1990, coincident with the time when blood testing was implemented in Venezuela, HCV G2j did not seem to reach growth equilibrium during this period.<h4>Conclusions/significance</h4>Assuming the introduction of G2j from Africa during the slave trade, the high frequency of G2j found in Venezuela could suggest: 1- the introduction of African ethnic groups different from the ones introduced to Martinique or 2- the occurrence of a founder effect. This study represents an in-depth analysis of the subtype diversity of HCV in Venezuela, which is still unexplored in the Americas and deserves further studies.
format	article
author	Maria Z Sulbarán Federico A Di Lello Yoneira Sulbarán Clarisa Cosson Carmen L Loureiro Héctor R Rangel Jean F Cantaloube Rodolfo H Campos Gonzalo Moratorio Juan Cristina Flor H Pujol
author_facet	Maria Z Sulbarán Federico A Di Lello Yoneira Sulbarán Clarisa Cosson Carmen L Loureiro Héctor R Rangel Jean F Cantaloube Rodolfo H Campos Gonzalo Moratorio Juan Cristina Flor H Pujol
author_sort	Maria Z Sulbarán
title	Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
title_short	Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
title_full	Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
title_fullStr	Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
title_full_unstemmed	Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.
title_sort	genetic history of hepatitis c virus in venezuela: high diversity and long time of evolution of hcv genotype 2.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/3c6cb8b7c3da4db0930bdfd3cff9a92b
work_keys_str_mv	AT mariazsulbaran genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT federicoadilello genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT yoneirasulbaran genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT clarisacosson genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT carmenlloureiro genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT hectorrrangel genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT jeanfcantaloube genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT rodolfohcampos genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT gonzalomoratorio genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT juancristina genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2 AT florhpujol genetichistoryofhepatitiscvirusinvenezuelahighdiversityandlongtimeofevolutionofhcvgenotype2
_version_	1718424033608859648

Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.

Ejemplares similares