Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi

Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently availab...

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Autores principales:	Fatima Zohra Delma, Abdullah M. S. Al-Hatmi, Roger J. M. Brüggemann, Willem J. G. Melchers, Sybren de Hoog, Paul E. Verweij, Jochem B. Buil
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	5-fluorocytosine resistance molecular mechanisms Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3c6d6b39361d4dd599a285366b1341d7
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spelling	oai:doaj.org-article:3c6d6b39361d4dd599a285366b1341d72021-11-25T18:05:38ZMolecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi10.3390/jof71109092309-608Xhttps://doaj.org/article/3c6d6b39361d4dd599a285366b1341d72021-10-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/909https://doaj.org/toc/2309-608XEffective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.Fatima Zohra DelmaAbdullah M. S. Al-HatmiRoger J. M. BrüggemannWillem J. G. MelchersSybren de HoogPaul E. VerweijJochem B. BuilMDPI AGarticle5-fluorocytosineresistancemolecular mechanismsBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 909, p 909 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	5-fluorocytosine resistance molecular mechanisms Biology (General) QH301-705.5
spellingShingle	5-fluorocytosine resistance molecular mechanisms Biology (General) QH301-705.5 Fatima Zohra Delma Abdullah M. S. Al-Hatmi Roger J. M. Brüggemann Willem J. G. Melchers Sybren de Hoog Paul E. Verweij Jochem B. Buil Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
description	Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.
format	article
author	Fatima Zohra Delma Abdullah M. S. Al-Hatmi Roger J. M. Brüggemann Willem J. G. Melchers Sybren de Hoog Paul E. Verweij Jochem B. Buil
author_facet	Fatima Zohra Delma Abdullah M. S. Al-Hatmi Roger J. M. Brüggemann Willem J. G. Melchers Sybren de Hoog Paul E. Verweij Jochem B. Buil
author_sort	Fatima Zohra Delma
title	Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
title_short	Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
title_full	Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
title_fullStr	Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
title_full_unstemmed	Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
title_sort	molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3c6d6b39361d4dd599a285366b1341d7
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Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi

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