Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors

Background: While the number of cases of vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) has been increasing every year, there are currently no clinically effective treatment methods. At present, Xi-Xian-Tong-Shuan capsule is predominantly used in patients with acute cer...

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Autores principales:	Feng Yan, Yue Tian, Yuyou Huang, Qi Wang, Ping Liu, Ningqun Wang, Fangfang Zhao, Liyuan Zhong, Wuhan Hui, Yumin Luo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Chronic cerebral hypoperfusion Vascular cognitive impairment Xi-Xian-Tong-Shuan capsule White matter lesions Neurons loss Inflammation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3c6e709699834f3ba0478a6e8d9ef366
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spelling	oai:doaj.org-article:3c6e709699834f3ba0478a6e8d9ef3662021-11-22T04:18:00ZXi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors0753-332210.1016/j.biopha.2021.112453https://doaj.org/article/3c6e709699834f3ba0478a6e8d9ef3662022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012397https://doaj.org/toc/0753-3322Background: While the number of cases of vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) has been increasing every year, there are currently no clinically effective treatment methods. At present, Xi-Xian-Tong-Shuan capsule is predominantly used in patients with acute cerebral ischemia; however, its protective effect on CCH has rarely been reported. Objective: To explore the underlying mechanisms by which Xi-Xian-Tong-Shuan capsule alleviates cognitive impairment caused by CCH. Methods: A model of CCH was established in specific-pathogen-free (SPF)-grade male Sprague-Dawley (SD) rats using bilateral common carotid artery occlusion (BCCAO). Xi-Xian-Tong-Shuan capsules were intragastrically administered for 42 days after the BCCAO surgery. We then assessed for changes in cognitive function, expression levels of pro-inflammatory factors, and coagulation function as well as for the presence of white matter lesions and neuronal loss. One-way ANOVA and Tukey's test were used to analyze the experimental data. Results: The rats showed significant cognitive dysfunction after the BCCAO surgery along with white matter lesions, a loss of neurons, and elevated levels of inflammatory factors, all of which were significantly reversed after intervention with Xi-Xian-Tong-Shuan capsules. Conclusion: Xi-Xian-Tong-Shuan capsules can ameliorate vascular cognitive impairment in CCH rats by preventing damage of white matter, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors. Our study provides a new reference for the clinical treatment of chronic cerebral ischemia with Xi-Xian-Tong-Shuan capsules.Feng YanYue TianYuyou HuangQi WangPing LiuNingqun WangFangfang ZhaoLiyuan ZhongWuhan HuiYumin LuoElsevierarticleChronic cerebral hypoperfusionVascular cognitive impairmentXi-Xian-Tong-Shuan capsuleWhite matter lesionsNeurons lossInflammationTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112453- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic cerebral hypoperfusion Vascular cognitive impairment Xi-Xian-Tong-Shuan capsule White matter lesions Neurons loss Inflammation Therapeutics. Pharmacology RM1-950
spellingShingle	Chronic cerebral hypoperfusion Vascular cognitive impairment Xi-Xian-Tong-Shuan capsule White matter lesions Neurons loss Inflammation Therapeutics. Pharmacology RM1-950 Feng Yan Yue Tian Yuyou Huang Qi Wang Ping Liu Ningqun Wang Fangfang Zhao Liyuan Zhong Wuhan Hui Yumin Luo Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
description	Background: While the number of cases of vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) has been increasing every year, there are currently no clinically effective treatment methods. At present, Xi-Xian-Tong-Shuan capsule is predominantly used in patients with acute cerebral ischemia; however, its protective effect on CCH has rarely been reported. Objective: To explore the underlying mechanisms by which Xi-Xian-Tong-Shuan capsule alleviates cognitive impairment caused by CCH. Methods: A model of CCH was established in specific-pathogen-free (SPF)-grade male Sprague-Dawley (SD) rats using bilateral common carotid artery occlusion (BCCAO). Xi-Xian-Tong-Shuan capsules were intragastrically administered for 42 days after the BCCAO surgery. We then assessed for changes in cognitive function, expression levels of pro-inflammatory factors, and coagulation function as well as for the presence of white matter lesions and neuronal loss. One-way ANOVA and Tukey's test were used to analyze the experimental data. Results: The rats showed significant cognitive dysfunction after the BCCAO surgery along with white matter lesions, a loss of neurons, and elevated levels of inflammatory factors, all of which were significantly reversed after intervention with Xi-Xian-Tong-Shuan capsules. Conclusion: Xi-Xian-Tong-Shuan capsules can ameliorate vascular cognitive impairment in CCH rats by preventing damage of white matter, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors. Our study provides a new reference for the clinical treatment of chronic cerebral ischemia with Xi-Xian-Tong-Shuan capsules.
format	article
author	Feng Yan Yue Tian Yuyou Huang Qi Wang Ping Liu Ningqun Wang Fangfang Zhao Liyuan Zhong Wuhan Hui Yumin Luo
author_facet	Feng Yan Yue Tian Yuyou Huang Qi Wang Ping Liu Ningqun Wang Fangfang Zhao Liyuan Zhong Wuhan Hui Yumin Luo
author_sort	Feng Yan
title	Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
title_short	Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
title_full	Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
title_fullStr	Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
title_full_unstemmed	Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
title_sort	xi-xian-tong-shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/3c6e709699834f3ba0478a6e8d9ef366
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Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors

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