Maternal biological age assessed in early pregnancy is associated with gestational age at birth

Abstract Maternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic backgrou...

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Autores principales:	Eva E. Lancaster, Dana M. Lapato, Colleen Jackson-Cook, Jerome F. Strauss, Roxann Roberson-Nay, Timothy P. York
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c6edca1b93649af842f13719041114c
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spelling	oai:doaj.org-article:3c6edca1b93649af842f13719041114c2021-12-02T16:31:02ZMaternal biological age assessed in early pregnancy is associated with gestational age at birth10.1038/s41598-021-94281-72045-2322https://doaj.org/article/3c6edca1b93649af842f13719041114c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94281-7https://doaj.org/toc/2045-2322Abstract Maternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.Eva E. LancasterDana M. LapatoColleen Jackson-CookJerome F. StraussRoxann Roberson-NayTimothy P. YorkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva E. Lancaster Dana M. Lapato Colleen Jackson-Cook Jerome F. Strauss Roxann Roberson-Nay Timothy P. York Maternal biological age assessed in early pregnancy is associated with gestational age at birth
description	Abstract Maternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.
format	article
author	Eva E. Lancaster Dana M. Lapato Colleen Jackson-Cook Jerome F. Strauss Roxann Roberson-Nay Timothy P. York
author_facet	Eva E. Lancaster Dana M. Lapato Colleen Jackson-Cook Jerome F. Strauss Roxann Roberson-Nay Timothy P. York
author_sort	Eva E. Lancaster
title	Maternal biological age assessed in early pregnancy is associated with gestational age at birth
title_short	Maternal biological age assessed in early pregnancy is associated with gestational age at birth
title_full	Maternal biological age assessed in early pregnancy is associated with gestational age at birth
title_fullStr	Maternal biological age assessed in early pregnancy is associated with gestational age at birth
title_full_unstemmed	Maternal biological age assessed in early pregnancy is associated with gestational age at birth
title_sort	maternal biological age assessed in early pregnancy is associated with gestational age at birth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c6edca1b93649af842f13719041114c
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Maternal biological age assessed in early pregnancy is associated with gestational age at birth

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