MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expression predicts poor prognosis in...

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Autores principales:	James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S. Barlowe, Alexendar R. Perez, Benjamin H. Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J. Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M. Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D. Nimer, Michael G. Kharas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
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spelling	oai:doaj.org-article:3c73f9725b9740dfbe30b10dcaac4d492021-12-02T16:57:17ZMSI2 is required for maintaining activated myelodysplastic syndrome stem cells10.1038/ncomms107392041-1723https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d492016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10739https://doaj.org/toc/2041-1723Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expression predicts poor prognosis in patients affected by this disease.James TaggartTzu-Chieh HoElianna AminHaiming XuTrevor S. BarloweAlexendar R. PerezBenjamin H. DurhamPatrick TivnanRachel OkabeArthur ChowLy VuSun Mi ParkCamila PrietoChristopher FamulareMinal PatelChristopher J. LengnerAmit VermaGail RobozMonica GuzmanVirginia M. KlimekOmar Abdel-WahabChristina LeslieStephen D. NimerMichael G. KharasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James Taggart Tzu-Chieh Ho Elianna Amin Haiming Xu Trevor S. Barlowe Alexendar R. Perez Benjamin H. Durham Patrick Tivnan Rachel Okabe Arthur Chow Ly Vu Sun Mi Park Camila Prieto Christopher Famulare Minal Patel Christopher J. Lengner Amit Verma Gail Roboz Monica Guzman Virginia M. Klimek Omar Abdel-Wahab Christina Leslie Stephen D. Nimer Michael G. Kharas MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
description	Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expression predicts poor prognosis in patients affected by this disease.
format	article
author	James Taggart Tzu-Chieh Ho Elianna Amin Haiming Xu Trevor S. Barlowe Alexendar R. Perez Benjamin H. Durham Patrick Tivnan Rachel Okabe Arthur Chow Ly Vu Sun Mi Park Camila Prieto Christopher Famulare Minal Patel Christopher J. Lengner Amit Verma Gail Roboz Monica Guzman Virginia M. Klimek Omar Abdel-Wahab Christina Leslie Stephen D. Nimer Michael G. Kharas
author_facet	James Taggart Tzu-Chieh Ho Elianna Amin Haiming Xu Trevor S. Barlowe Alexendar R. Perez Benjamin H. Durham Patrick Tivnan Rachel Okabe Arthur Chow Ly Vu Sun Mi Park Camila Prieto Christopher Famulare Minal Patel Christopher J. Lengner Amit Verma Gail Roboz Monica Guzman Virginia M. Klimek Omar Abdel-Wahab Christina Leslie Stephen D. Nimer Michael G. Kharas
author_sort	James Taggart
title	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
title_short	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
title_full	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
title_fullStr	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
title_full_unstemmed	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells
title_sort	msi2 is required for maintaining activated myelodysplastic syndrome stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
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MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

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