The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma
Abstract Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melan...
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Nature Portfolio
2021
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oai:doaj.org-article:3c74eed3d11a4242ad7acd2b924d74872021-12-02T14:11:29ZThe multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma10.1038/s41598-021-83169-12045-2322https://doaj.org/article/3c74eed3d11a4242ad7acd2b924d74872021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83169-1https://doaj.org/toc/2045-2322Abstract Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours.Itziar Urizar-ArenazaAitor BenedictoArantza Perez-ValleNerea OsinaldeVyacheslav AkimovIraia Muñoa-HoyosJose Antonio RodriguezAintzane AsumendiMaria Dolores BoyanoBlagoy BlagoevIrina KratchmarovaNerea SubiranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Itziar Urizar-Arenaza Aitor Benedicto Arantza Perez-Valle Nerea Osinalde Vyacheslav Akimov Iraia Muñoa-Hoyos Jose Antonio Rodriguez Aintzane Asumendi Maria Dolores Boyano Blagoy Blagoev Irina Kratchmarova Nerea Subiran The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| description |
Abstract Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours. |
| format |
article |
| author |
Itziar Urizar-Arenaza Aitor Benedicto Arantza Perez-Valle Nerea Osinalde Vyacheslav Akimov Iraia Muñoa-Hoyos Jose Antonio Rodriguez Aintzane Asumendi Maria Dolores Boyano Blagoy Blagoev Irina Kratchmarova Nerea Subiran |
| author_facet |
Itziar Urizar-Arenaza Aitor Benedicto Arantza Perez-Valle Nerea Osinalde Vyacheslav Akimov Iraia Muñoa-Hoyos Jose Antonio Rodriguez Aintzane Asumendi Maria Dolores Boyano Blagoy Blagoev Irina Kratchmarova Nerea Subiran |
| author_sort |
Itziar Urizar-Arenaza |
| title |
The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| title_short |
The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| title_full |
The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| title_fullStr |
The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| title_full_unstemmed |
The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| title_sort |
multifunctional role of spanx-a/d protein subfamily in the promotion of pro-tumoural processes in human melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3c74eed3d11a4242ad7acd2b924d7487 |
| work_keys_str_mv |
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