Discovery of a new class of integrin antibodies for fibrosis

Discovery of a new class of integrin antibodies for fibrosis

Abstract Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types of cancer. We previously discovered that MK-0429 is an equipotent pan-inhibitor of αv integrins that reduces prot...

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Main Authors: Ji Zhang, Tao Wang, Ashmita Saigal, Josephine Johnson, Jennifer Morrisson, Sahba Tabrizifard, Scott A. Hollingsworth, Michael J. Eddins, Wenxian Mao, Kim O’Neill, Margarita Garcia-Calvo, Ester Carballo-Jane, DingGang Liu, Taewon Ham, Qiong Zhou, Weifeng Dong, Hsien-Wei Meng, Jacqueline Hicks, Tian-Quan Cai, Taro Akiyama, Shirly Pinto, Alan C. Cheng, Thomas Greshock, John C. Marquis, Zhao Ren, Saswata Talukdar, Hussam Hisham Shaheen, Masahisa Handa
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/3c77d995775e4a3aa500d4b475ea8591
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https://doaj.org/article/3c77d995775e4a3aa500d4b475ea8591

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