The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome

Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials and methods. We analysed the histological (light microscopy) and immunohistochemical (CD31, CD68, osteopontin, MMP-9 and TIMP-1) features of tissue re...

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Autores principales:	Ekaterina L. Zaitseva, Ludmila P. Doronina, Roman V. Molchkov, Iya A. Voronkova, Alla Y. Tokmakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetes mellitus chronic wounds repair immunohistochemistry histology repair markers Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/3c7864f735d240bdbd49ee25a72296de
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spelling	oai:doaj.org-article:3c7864f735d240bdbd49ee25a72296de2021-11-14T09:00:20ZThe morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome2072-03512072-037810.14341/DM7587https://doaj.org/article/3c7864f735d240bdbd49ee25a72296de2015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7587https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials and methods. We analysed the histological (light microscopy) and immunohistochemical (CD31, CD68, osteopontin, MMP-9 and TIMP-1) features of tissue repair processes in patients with diabetes mellitus. The study involved 63 patients with diabetic foot syndrome after surgical debridement.Results. We found severe intercellular oedema, poorly organised extracellular matrix, small amounts of fibroblast-like cells and expressed inflammatory infiltration, along with the presence of young granulation tissue. According to the results of the immunohistochemical studies, there were a moderate number of macrophages (immunopositive with antibodies to CD68), intense staining of MMP-9 and weak staining of TIMP-1 and osteopontin.Conclusion. According to the findings of the histological and immunohistochemical studies, tissue repair processes in patients with diabetes mellitus are decelerated.Ekaterina L. ZaitsevaLudmila P. DoroninaRoman V. MolchkovIya A. VoronkovaAlla Y. TokmakovaEndocrinology Research Centrearticlediabetes mellituschronic woundsrepairimmunohistochemistryhistologyrepair markersNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 72-78 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus chronic wounds repair immunohistochemistry histology repair markers Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus chronic wounds repair immunohistochemistry histology repair markers Nutritional diseases. Deficiency diseases RC620-627 Ekaterina L. Zaitseva Ludmila P. Doronina Roman V. Molchkov Iya A. Voronkova Alla Y. Tokmakova The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
description	Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials and methods. We analysed the histological (light microscopy) and immunohistochemical (CD31, CD68, osteopontin, MMP-9 and TIMP-1) features of tissue repair processes in patients with diabetes mellitus. The study involved 63 patients with diabetic foot syndrome after surgical debridement.Results. We found severe intercellular oedema, poorly organised extracellular matrix, small amounts of fibroblast-like cells and expressed inflammatory infiltration, along with the presence of young granulation tissue. According to the results of the immunohistochemical studies, there were a moderate number of macrophages (immunopositive with antibodies to CD68), intense staining of MMP-9 and weak staining of TIMP-1 and osteopontin.Conclusion. According to the findings of the histological and immunohistochemical studies, tissue repair processes in patients with diabetes mellitus are decelerated.
format	article
author	Ekaterina L. Zaitseva Ludmila P. Doronina Roman V. Molchkov Iya A. Voronkova Alla Y. Tokmakova
author_facet	Ekaterina L. Zaitseva Ludmila P. Doronina Roman V. Molchkov Iya A. Voronkova Alla Y. Tokmakova
author_sort	Ekaterina L. Zaitseva
title	The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
title_short	The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
title_full	The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
title_fullStr	The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
title_full_unstemmed	The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
title_sort	morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/3c7864f735d240bdbd49ee25a72296de
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The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome

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