Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel

Tricyclic furanic compounds with multiple chiral centers are found in a variety of natural products. Here, the authors show a highly enantioselective nickel-catalyzed procedure to access tricyclic oxygen-containing scaffolds with five contiguous chiral centers.

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Auteurs principaux:	Ravindra Kumar, Yoichi Hoshimoto, Eri Tamai, Masato Ohashi, Sensuke Ogoshi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3c787649d39c4ad8b5b8b89e6d424d32
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spelling	oai:doaj.org-article:3c787649d39c4ad8b5b8b89e6d424d322021-12-02T10:47:59ZTwo-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel10.1038/s41467-017-00068-82041-1723https://doaj.org/article/3c787649d39c4ad8b5b8b89e6d424d322017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00068-8https://doaj.org/toc/2041-1723Tricyclic furanic compounds with multiple chiral centers are found in a variety of natural products. Here, the authors show a highly enantioselective nickel-catalyzed procedure to access tricyclic oxygen-containing scaffolds with five contiguous chiral centers.Ravindra KumarYoichi HoshimotoEri TamaiMasato OhashiSensuke OgoshiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ravindra Kumar Yoichi Hoshimoto Eri Tamai Masato Ohashi Sensuke Ogoshi Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
description	Tricyclic furanic compounds with multiple chiral centers are found in a variety of natural products. Here, the authors show a highly enantioselective nickel-catalyzed procedure to access tricyclic oxygen-containing scaffolds with five contiguous chiral centers.
format	article
author	Ravindra Kumar Yoichi Hoshimoto Eri Tamai Masato Ohashi Sensuke Ogoshi
author_facet	Ravindra Kumar Yoichi Hoshimoto Eri Tamai Masato Ohashi Sensuke Ogoshi
author_sort	Ravindra Kumar
title	Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
title_short	Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
title_full	Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
title_fullStr	Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
title_full_unstemmed	Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
title_sort	two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3c787649d39c4ad8b5b8b89e6d424d32
work_keys_str_mv	AT ravindrakumar twostepsynthesisofchiralfusedtricyclicscaffoldsfromphenolsviadesymmetrizationonnickel AT yoichihoshimoto twostepsynthesisofchiralfusedtricyclicscaffoldsfromphenolsviadesymmetrizationonnickel AT eritamai twostepsynthesisofchiralfusedtricyclicscaffoldsfromphenolsviadesymmetrizationonnickel AT masatoohashi twostepsynthesisofchiralfusedtricyclicscaffoldsfromphenolsviadesymmetrizationonnickel AT sensukeogoshi twostepsynthesisofchiralfusedtricyclicscaffoldsfromphenolsviadesymmetrizationonnickel
_version_	1718396704177258496

Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel

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