Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loade...

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Autores principales:	Xiaoyong Yang, Qinzhe Wang, Erhu Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c7bbf82d06b49a88e2a0dccd9025790
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spelling	oai:doaj.org-article:3c7bbf82d06b49a88e2a0dccd90257902021-12-02T14:40:28ZStructure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy10.1038/s41467-020-14790-32041-1723https://doaj.org/article/3c7bbf82d06b49a88e2a0dccd90257902020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14790-3https://doaj.org/toc/2041-1723The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loaded, inward-open state and discuss the transport mechanism.Xiaoyong YangQinzhe WangErhu CaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyong Yang Qinzhe Wang Erhu Cao Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
description	The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loaded, inward-open state and discuss the transport mechanism.
format	article
author	Xiaoyong Yang Qinzhe Wang Erhu Cao
author_facet	Xiaoyong Yang Qinzhe Wang Erhu Cao
author_sort	Xiaoyong Yang
title	Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_short	Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_full	Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_fullStr	Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_full_unstemmed	Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_sort	structure of the human cation–chloride cotransporter nkcc1 determined by single-particle electron cryo-microscopy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c7bbf82d06b49a88e2a0dccd9025790
work_keys_str_mv	AT xiaoyongyang structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy AT qinzhewang structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy AT erhucao structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy
_version_	1718390289148674048

Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

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