MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.

MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased levels of p27(KIP) and temporary growth arrest of CHO...

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Autores principales: Noelia Sanchez, Mark Gallagher, Nga Lao, Clair Gallagher, Colin Clarke, Padraig Doolan, Sinead Aherne, Alfonso Blanco, Paula Meleady, Martin Clynes, Niall Barron
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3c7d73595041443e97e7b24bd5130b88
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