Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

Ischemic stroke (IS) is a disease that is characterized by high mortality and disability. Recent studies have shown that LncRNA-mediated competing endogenous RNA (ceRNA) networks play roles in the occurrence and development of cerebral I/R injury by regulating different signaling pathways. However,...

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Autores principales:	Shuxia Zhang, Ting Zhu, Qiaoyu Li, Guibo Sun, Xiaobo Sun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	long non-coding RNA competing endogenous RNA network ischemic stroke ischemia-reperfusion injury therapeutic target Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3c8081c892d94400a4dd0e90e0bb00a8
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spelling	oai:doaj.org-article:3c8081c892d94400a4dd0e90e0bb00a82021-11-17T05:44:30ZLong Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges1663-981210.3389/fphar.2021.765075https://doaj.org/article/3c8081c892d94400a4dd0e90e0bb00a82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.765075/fullhttps://doaj.org/toc/1663-9812Ischemic stroke (IS) is a disease that is characterized by high mortality and disability. Recent studies have shown that LncRNA-mediated competing endogenous RNA (ceRNA) networks play roles in the occurrence and development of cerebral I/R injury by regulating different signaling pathways. However, no systematic analysis of ceRNA mechanisms in IS has been reported. In this review, we discuss molecular mechanisms of LncRNA-mediated ceRNA networks under I/R injury. The expression levels of LncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) and their effects in four major cell types of the neurovascular unit (NVU) are also involved. We further summarize studies of LncRNAs as biomarkers and therapeutic targets. Finally, we analyze the advantages and limitations of using LncRNAs as therapeutics for IS.Shuxia ZhangShuxia ZhangShuxia ZhangShuxia ZhangShuxia ZhangTing ZhuQiaoyu LiQiaoyu LiQiaoyu LiQiaoyu LiQiaoyu LiGuibo SunGuibo SunGuibo SunGuibo SunGuibo SunXiaobo SunXiaobo SunXiaobo SunXiaobo SunXiaobo SunFrontiers Media S.A.articlelong non-coding RNAcompeting endogenous RNA networkischemic strokeischemia-reperfusion injurytherapeutic targetTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA competing endogenous RNA network ischemic stroke ischemia-reperfusion injury therapeutic target Therapeutics. Pharmacology RM1-950
spellingShingle	long non-coding RNA competing endogenous RNA network ischemic stroke ischemia-reperfusion injury therapeutic target Therapeutics. Pharmacology RM1-950 Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Ting Zhu Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Guibo Sun Guibo Sun Guibo Sun Guibo Sun Guibo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
description	Ischemic stroke (IS) is a disease that is characterized by high mortality and disability. Recent studies have shown that LncRNA-mediated competing endogenous RNA (ceRNA) networks play roles in the occurrence and development of cerebral I/R injury by regulating different signaling pathways. However, no systematic analysis of ceRNA mechanisms in IS has been reported. In this review, we discuss molecular mechanisms of LncRNA-mediated ceRNA networks under I/R injury. The expression levels of LncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) and their effects in four major cell types of the neurovascular unit (NVU) are also involved. We further summarize studies of LncRNAs as biomarkers and therapeutic targets. Finally, we analyze the advantages and limitations of using LncRNAs as therapeutics for IS.
format	article
author	Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Ting Zhu Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Guibo Sun Guibo Sun Guibo Sun Guibo Sun Guibo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun
author_facet	Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Ting Zhu Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Guibo Sun Guibo Sun Guibo Sun Guibo Sun Guibo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun
author_sort	Shuxia Zhang
title	Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
title_short	Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
title_full	Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
title_fullStr	Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
title_full_unstemmed	Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
title_sort	long non-coding rna-mediated competing endogenous rna networks in ischemic stroke: molecular mechanisms, therapeutic implications, and challenges
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3c8081c892d94400a4dd0e90e0bb00a8
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Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

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