The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells
Abstract Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/3c81dba573894f44b340dafd88a5e78b |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|