CD4+ T cell immunity to Salmonella is transient in the circulation.

While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen specificities. Exploiting a mouse model of vaccin...

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Autores principales:	Newton G Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M Shreenivas, Ian Comerford, Dianna M Hocking, Anna B Erazo, Irmgard Förster, Andreas Kupz, Thomas Gebhardt, Shaun R McColl, Stephen J McSorley, Sammy Bedoui, Richard A Strugnell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3c84a0cce3d2446fb317538977d6aa8e
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spelling	oai:doaj.org-article:3c84a0cce3d2446fb317538977d6aa8e2021-12-02T19:59:59ZCD4+ T cell immunity to Salmonella is transient in the circulation.1553-73661553-737410.1371/journal.ppat.1010004https://doaj.org/article/3c84a0cce3d2446fb317538977d6aa8e2021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1010004https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen specificities. Exploiting a mouse model of vaccination, we show that the spleens of C57BL/6 mice vaccinated with live-attenuated Salmonella serovar Typhimurium (S. Typhimurium) strains carried a pool of IFN-γ+ CD4+ T cells that could adoptively transfer protection, but only transiently. Circulating Salmonella-reactive CD4+ T cells expressed the liver-homing chemokine receptor CXCR6, accumulated over time in the liver and assumed phenotypic characteristics associated with tissue-associated T cells. Liver memory CD4+ T cells showed TCR selection bias and their accumulation in the liver could be inhibited by blocking CXCL16. These data showed that the circulation of CD4+ T cells mediating immunity to Salmonella is limited to a brief window after which Salmonella-specific CD4+ T cells migrate to peripheral tissues. Our observations highlight the importance of triggering tissue-specific immunity against systemic infections.Newton G PeresNancy WangPaul WhitneySven EngelMeghanashree M ShreenivasIan ComerfordDianna M HockingAnna B ErazoIrmgard FörsterAndreas KupzThomas GebhardtShaun R McCollStephen J McSorleySammy BedouiRichard A StrugnellPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1010004 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Newton G Peres Nancy Wang Paul Whitney Sven Engel Meghanashree M Shreenivas Ian Comerford Dianna M Hocking Anna B Erazo Irmgard Förster Andreas Kupz Thomas Gebhardt Shaun R McColl Stephen J McSorley Sammy Bedoui Richard A Strugnell CD4+ T cell immunity to Salmonella is transient in the circulation.
description	While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen specificities. Exploiting a mouse model of vaccination, we show that the spleens of C57BL/6 mice vaccinated with live-attenuated Salmonella serovar Typhimurium (S. Typhimurium) strains carried a pool of IFN-γ+ CD4+ T cells that could adoptively transfer protection, but only transiently. Circulating Salmonella-reactive CD4+ T cells expressed the liver-homing chemokine receptor CXCR6, accumulated over time in the liver and assumed phenotypic characteristics associated with tissue-associated T cells. Liver memory CD4+ T cells showed TCR selection bias and their accumulation in the liver could be inhibited by blocking CXCL16. These data showed that the circulation of CD4+ T cells mediating immunity to Salmonella is limited to a brief window after which Salmonella-specific CD4+ T cells migrate to peripheral tissues. Our observations highlight the importance of triggering tissue-specific immunity against systemic infections.
format	article
author	Newton G Peres Nancy Wang Paul Whitney Sven Engel Meghanashree M Shreenivas Ian Comerford Dianna M Hocking Anna B Erazo Irmgard Förster Andreas Kupz Thomas Gebhardt Shaun R McColl Stephen J McSorley Sammy Bedoui Richard A Strugnell
author_facet	Newton G Peres Nancy Wang Paul Whitney Sven Engel Meghanashree M Shreenivas Ian Comerford Dianna M Hocking Anna B Erazo Irmgard Förster Andreas Kupz Thomas Gebhardt Shaun R McColl Stephen J McSorley Sammy Bedoui Richard A Strugnell
author_sort	Newton G Peres
title	CD4+ T cell immunity to Salmonella is transient in the circulation.
title_short	CD4+ T cell immunity to Salmonella is transient in the circulation.
title_full	CD4+ T cell immunity to Salmonella is transient in the circulation.
title_fullStr	CD4+ T cell immunity to Salmonella is transient in the circulation.
title_full_unstemmed	CD4+ T cell immunity to Salmonella is transient in the circulation.
title_sort	cd4+ t cell immunity to salmonella is transient in the circulation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3c84a0cce3d2446fb317538977d6aa8e
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CD4+ T cell immunity to Salmonella is transient in the circulation.

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