Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy

Photodynamic therapy (PDT) has attracted tremendous attention in the antitumor and antimicrobial areas. To enhance the water solubility of photosensitizers and facilitate their accumulation in the tumor/infection site, polymeric materials are frequently explored as delivery systems, which are expect...

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Autores principales:	Zhijia Wang, Fu-Jian Xu, Bingran Yu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	polymer target activatable photodynamic therapy antibacterial Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/3c85d5d6af674babbb6646c5001cb228
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spelling	oai:doaj.org-article:3c85d5d6af674babbb6646c5001cb2282021-11-04T05:09:20ZSmart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy2296-418510.3389/fbioe.2021.783354https://doaj.org/article/3c85d5d6af674babbb6646c5001cb2282021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.783354/fullhttps://doaj.org/toc/2296-4185Photodynamic therapy (PDT) has attracted tremendous attention in the antitumor and antimicrobial areas. To enhance the water solubility of photosensitizers and facilitate their accumulation in the tumor/infection site, polymeric materials are frequently explored as delivery systems, which are expected to show target and controllable activation of photosensitizers. This review introduces the smart polymeric delivery systems for the PDT of tumor and bacterial infections. In particular, strategies that are tumor/bacteria targeted or activatable by the tumor/bacteria microenvironment such as enzyme/pH/reactive oxygen species (ROS) are summarized. The similarities and differences of polymeric delivery systems in antitumor and antimicrobial PDT are compared. Finally, the potential challenges and perspectives of those polymeric delivery systems are discussed.Zhijia WangFu-Jian XuBingran YuFrontiers Media S.A.articlepolymertargetactivatablephotodynamic therapyantibacterialBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymer target activatable photodynamic therapy antibacterial Biotechnology TP248.13-248.65
spellingShingle	polymer target activatable photodynamic therapy antibacterial Biotechnology TP248.13-248.65 Zhijia Wang Fu-Jian Xu Bingran Yu Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
description	Photodynamic therapy (PDT) has attracted tremendous attention in the antitumor and antimicrobial areas. To enhance the water solubility of photosensitizers and facilitate their accumulation in the tumor/infection site, polymeric materials are frequently explored as delivery systems, which are expected to show target and controllable activation of photosensitizers. This review introduces the smart polymeric delivery systems for the PDT of tumor and bacterial infections. In particular, strategies that are tumor/bacteria targeted or activatable by the tumor/bacteria microenvironment such as enzyme/pH/reactive oxygen species (ROS) are summarized. The similarities and differences of polymeric delivery systems in antitumor and antimicrobial PDT are compared. Finally, the potential challenges and perspectives of those polymeric delivery systems are discussed.
format	article
author	Zhijia Wang Fu-Jian Xu Bingran Yu
author_facet	Zhijia Wang Fu-Jian Xu Bingran Yu
author_sort	Zhijia Wang
title	Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
title_short	Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
title_full	Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
title_fullStr	Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
title_full_unstemmed	Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy
title_sort	smart polymeric delivery system for antitumor and antimicrobial photodynamic therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3c85d5d6af674babbb6646c5001cb228
work_keys_str_mv	AT zhijiawang smartpolymericdeliverysystemforantitumorandantimicrobialphotodynamictherapy AT fujianxu smartpolymericdeliverysystemforantitumorandantimicrobialphotodynamictherapy AT bingranyu smartpolymericdeliverysystemforantitumorandantimicrobialphotodynamictherapy
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Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy

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