Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

Formylpeptide receptors (FPRs) are a class of chemotactic G protein-coupled receptors (GPCRs) that recognize pathogen- and host-derived formylpeptides. Here the authors report the 3.17 Å cryo-EM structure of the human FPR2-Gi signaling complex with a bound peptide agonist and in combination with com...

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Autores principales:	Youwen Zhuang, Heng Liu, X. Edward Zhou, Ravi Kumar Verma, Parker W. de Waal, Wonjo Jang, Ting-Hai Xu, Lei Wang, Xing Meng, Gongpu Zhao, Yanyong Kang, Karsten Melcher, Hao Fan, Nevin A. Lambert, H. Eric Xu, Cheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c877c5e058b47a68a52db49730981f1
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spelling	oai:doaj.org-article:3c877c5e058b47a68a52db49730981f12021-12-02T17:32:59ZStructure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling10.1038/s41467-020-14728-92041-1723https://doaj.org/article/3c877c5e058b47a68a52db49730981f12020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14728-9https://doaj.org/toc/2041-1723Formylpeptide receptors (FPRs) are a class of chemotactic G protein-coupled receptors (GPCRs) that recognize pathogen- and host-derived formylpeptides. Here the authors report the 3.17 Å cryo-EM structure of the human FPR2-Gi signaling complex with a bound peptide agonist and in combination with computational docking and MD simulations provide mechanistic insights into formylpeptide recognition by FPRs.Youwen ZhuangHeng LiuX. Edward ZhouRavi Kumar VermaParker W. de WaalWonjo JangTing-Hai XuLei WangXing MengGongpu ZhaoYanyong KangKarsten MelcherHao FanNevin A. LambertH. Eric XuCheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youwen Zhuang Heng Liu X. Edward Zhou Ravi Kumar Verma Parker W. de Waal Wonjo Jang Ting-Hai Xu Lei Wang Xing Meng Gongpu Zhao Yanyong Kang Karsten Melcher Hao Fan Nevin A. Lambert H. Eric Xu Cheng Zhang Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
description	Formylpeptide receptors (FPRs) are a class of chemotactic G protein-coupled receptors (GPCRs) that recognize pathogen- and host-derived formylpeptides. Here the authors report the 3.17 Å cryo-EM structure of the human FPR2-Gi signaling complex with a bound peptide agonist and in combination with computational docking and MD simulations provide mechanistic insights into formylpeptide recognition by FPRs.
format	article
author	Youwen Zhuang Heng Liu X. Edward Zhou Ravi Kumar Verma Parker W. de Waal Wonjo Jang Ting-Hai Xu Lei Wang Xing Meng Gongpu Zhao Yanyong Kang Karsten Melcher Hao Fan Nevin A. Lambert H. Eric Xu Cheng Zhang
author_facet	Youwen Zhuang Heng Liu X. Edward Zhou Ravi Kumar Verma Parker W. de Waal Wonjo Jang Ting-Hai Xu Lei Wang Xing Meng Gongpu Zhao Yanyong Kang Karsten Melcher Hao Fan Nevin A. Lambert H. Eric Xu Cheng Zhang
author_sort	Youwen Zhuang
title	Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
title_short	Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
title_full	Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
title_fullStr	Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
title_full_unstemmed	Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
title_sort	structure of formylpeptide receptor 2-gi complex reveals insights into ligand recognition and signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c877c5e058b47a68a52db49730981f1
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Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

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