Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.

<h4>Background</h4>Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS has been associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, li...

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Autores principales:	Binghai Zhao, Li Li, Jieting Liu, Hongzhi Li, Chunlei Zhang, Pengfei Han, Yufei Zhang, Xiaohuan Yuan, Ren Shan Ge, Yanhui Chu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c897eb58ede47a9a645584dddae80a8
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spelling	oai:doaj.org-article:3c897eb58ede47a9a645584dddae80a82021-11-18T08:37:53ZExposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.1932-620310.1371/journal.pone.0078888https://doaj.org/article/3c897eb58ede47a9a645584dddae80a82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454680/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS has been associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, little is known about PFOS effects in utero on fetal Leydig cells (FLC).<h4>Methods and results</h4>The present study investigated effects of PFOS on FLC function. Pregnant Sprague Dawley female rats received vehicle (0.05% Tween20) or PFOS (5, 20 mg/kg) by oral gavage from gestational day (GD) 11-19. At GD20, testosterone (T) production, FLC numbers and ultrastructure, testicular gene and protein expression levels were examined. The results indicate that exposures to PFOS have affected FLC function as evidenced by decreased T production, impaired FLC, reduced FLC number, and decreased steroidogenic capacity and cholesterol level in utero.<h4>Conclusion</h4>The present study shows that PFOS is an endocrine disruptor of male reproductive system as it causes reduction of T production and impairment of rat fetal Leydig cells.Binghai ZhaoLi LiJieting LiuHongzhi LiChunlei ZhangPengfei HanYufei ZhangXiaohuan YuanRen Shan GeYanhui ChuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e78888 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binghai Zhao Li Li Jieting Liu Hongzhi Li Chunlei Zhang Pengfei Han Yufei Zhang Xiaohuan Yuan Ren Shan Ge Yanhui Chu Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
description	<h4>Background</h4>Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS has been associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, little is known about PFOS effects in utero on fetal Leydig cells (FLC).<h4>Methods and results</h4>The present study investigated effects of PFOS on FLC function. Pregnant Sprague Dawley female rats received vehicle (0.05% Tween20) or PFOS (5, 20 mg/kg) by oral gavage from gestational day (GD) 11-19. At GD20, testosterone (T) production, FLC numbers and ultrastructure, testicular gene and protein expression levels were examined. The results indicate that exposures to PFOS have affected FLC function as evidenced by decreased T production, impaired FLC, reduced FLC number, and decreased steroidogenic capacity and cholesterol level in utero.<h4>Conclusion</h4>The present study shows that PFOS is an endocrine disruptor of male reproductive system as it causes reduction of T production and impairment of rat fetal Leydig cells.
format	article
author	Binghai Zhao Li Li Jieting Liu Hongzhi Li Chunlei Zhang Pengfei Han Yufei Zhang Xiaohuan Yuan Ren Shan Ge Yanhui Chu
author_facet	Binghai Zhao Li Li Jieting Liu Hongzhi Li Chunlei Zhang Pengfei Han Yufei Zhang Xiaohuan Yuan Ren Shan Ge Yanhui Chu
author_sort	Binghai Zhao
title	Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
title_short	Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
title_full	Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
title_fullStr	Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
title_full_unstemmed	Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
title_sort	exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal leydig cells.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3c897eb58ede47a9a645584dddae80a8
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Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.

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