SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at common fragile sites.

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Autores principales: Min Li, Xiaohua Xu, Chou-Wei Chang, Li Zheng, Binghui Shen, Yilun Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3c8aaa721b264e04b78ccefcddd41b2c
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spelling oai:doaj.org-article:3c8aaa721b264e04b78ccefcddd41b2c2021-12-02T16:49:38ZSUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts10.1038/s41467-018-05236-y2041-1723https://doaj.org/article/3c8aaa721b264e04b78ccefcddd41b2c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05236-yhttps://doaj.org/toc/2041-1723Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at common fragile sites.Min LiXiaohua XuChou-Wei ChangLi ZhengBinghui ShenYilun LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Li
Xiaohua Xu
Chou-Wei Chang
Li Zheng
Binghui Shen
Yilun Liu
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
description Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at common fragile sites.
format article
author Min Li
Xiaohua Xu
Chou-Wei Chang
Li Zheng
Binghui Shen
Yilun Liu
author_facet Min Li
Xiaohua Xu
Chou-Wei Chang
Li Zheng
Binghui Shen
Yilun Liu
author_sort Min Li
title SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
title_short SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
title_full SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
title_fullStr SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
title_full_unstemmed SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
title_sort sumo2 conjugation of pcna facilitates chromatin remodeling to resolve transcription-replication conflicts
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3c8aaa721b264e04b78ccefcddd41b2c
work_keys_str_mv AT minli sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
AT xiaohuaxu sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
AT chouweichang sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
AT lizheng sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
AT binghuishen sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
AT yilunliu sumo2conjugationofpcnafacilitateschromatinremodelingtoresolvetranscriptionreplicationconflicts
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