SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at common fragile sites.

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Autores principales: Min Li, Xiaohua Xu, Chou-Wei Chang, Li Zheng, Binghui Shen, Yilun Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/3c8aaa721b264e04b78ccefcddd41b2c
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