Risk definition and management strategies in retinoblastoma: current perspectives

Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatmen...

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Autores principales:	Ghassemi F, Khodabande A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3c8b685f164343a282b395d32fa9f8de
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spelling	oai:doaj.org-article:3c8b685f164343a282b395d32fa9f8de2021-12-02T01:19:26ZRisk definition and management strategies in retinoblastoma: current perspectives1177-5483https://doaj.org/article/3c8b685f164343a282b395d32fa9f8de2015-06-01T00:00:00Zhttp://www.dovepress.com/risk-definition-and-management-strategies-in-retinoblastoma-current-pe-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatments of retinoblastoma. Presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Currently, globe-sparing therapies, including systemic chemotherapy, intra-arterial chemoreduction, intravitreal chemotherapy, focal consolidation, and combination therapies, are being used and investigated actively. Major advances are being made in the diagnosis and management of retinoblastoma that will lead to improved morbidity and mortality rates in patients with retinoblastoma. By saving the globes, fronting with some high-risk factors for metastasis would be inevitable. International multi-institutional prospective studies could resolve current uncertainties regarding the main tumor treatment regimens for each patient and indications for chemoprophylaxis for high-risk-factor-bearing retinoblastoma cases. Keywords: retinoblastoma, intra-arterial chemotherapy, systemic chemotherapyGhassemi FKhodabande ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 985-994 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ghassemi F Khodabande A Risk definition and management strategies in retinoblastoma: current perspectives
description	Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatments of retinoblastoma. Presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Currently, globe-sparing therapies, including systemic chemotherapy, intra-arterial chemoreduction, intravitreal chemotherapy, focal consolidation, and combination therapies, are being used and investigated actively. Major advances are being made in the diagnosis and management of retinoblastoma that will lead to improved morbidity and mortality rates in patients with retinoblastoma. By saving the globes, fronting with some high-risk factors for metastasis would be inevitable. International multi-institutional prospective studies could resolve current uncertainties regarding the main tumor treatment regimens for each patient and indications for chemoprophylaxis for high-risk-factor-bearing retinoblastoma cases. Keywords: retinoblastoma, intra-arterial chemotherapy, systemic chemotherapy
format	article
author	Ghassemi F Khodabande A
author_facet	Ghassemi F Khodabande A
author_sort	Ghassemi F
title	Risk definition and management strategies in retinoblastoma: current perspectives
title_short	Risk definition and management strategies in retinoblastoma: current perspectives
title_full	Risk definition and management strategies in retinoblastoma: current perspectives
title_fullStr	Risk definition and management strategies in retinoblastoma: current perspectives
title_full_unstemmed	Risk definition and management strategies in retinoblastoma: current perspectives
title_sort	risk definition and management strategies in retinoblastoma: current perspectives
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3c8b685f164343a282b395d32fa9f8de
work_keys_str_mv	AT ghassemif riskdefinitionandmanagementstrategiesinretinoblastomacurrentperspectives AT khodabandea riskdefinitionandmanagementstrategiesinretinoblastomacurrentperspectives
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Risk definition and management strategies in retinoblastoma: current perspectives

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